{"id":"W2032347134","doi":"10.1158/1538-7445.am2014-992","title":"Abstract 992: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Biology; Motility; LIM domain; Effector; Cell biology; Tumor progression; Metastasis; Cancer research; Focal adhesion; Scaffold protein; Integrin; Integrin-linked kinase; Cytoplasm; Gene knockdown; Signal transduction; Cell; Cancer; Cell culture; Kinase; Transcription factor; Protein kinase A; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008466486,0.0003818763,0.0002195793,0.0001966846,0.0001809572,0.0002310015,0.0002195109,0.0003335572,0.001603923],"category_scores_gemma":[0.00009587806,0.0001206892,0.0002409415,0.0001839588,0.0002556347,0.0001181664,0.0001777297,0.0003964794,0.0007105546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004800484,"about_ca_system_score_gemma":0.0001548881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004781475,"about_ca_topic_score_gemma":0.0003675966,"domain_scores_codex":[0.999918,0.000009497067,0.000007870057,0.00002157295,0.00002795238,0.00001507739],"domain_scores_gemma":[0.9999417,0.000007698869,0.00001298487,0.000004166872,0.000006673556,0.00002672624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007825927,0.00001288343,0.0001294058,0.00002367282,0.00000422641,0.00020489,0.00000386547,0.00003817542,0.9990804,0.00004263226,0.00009095349,0.0002906193],"study_design_scores_gemma":[0.00003867551,0.0001576128,0.003580823,0.00000575795,0.00001906523,0.001470465,0.00001758116,0.00105138,0.9878286,0.00004339265,0.005780183,0.000006443655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882284,0.001889866,0.003822386,0.0003459674,0.0001473681,0.00005868978,0.002844572,0.0001740064,0.002488765],"genre_scores_gemma":[0.9824028,0.0006441033,0.003801965,0.0001241099,0.00003630625,0.00006602046,0.00538409,0.00004957954,0.007490901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001603923,"threshold_uncertainty_score":0.00536567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.068249639759962,"score_gpt":0.3905374617361272,"score_spread":0.3222878219761652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}