{"id":"W2032352567","doi":"10.4161/auto.29639","title":"BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy","year":2014,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Australian Government","keywords":"Autophagy; BECN1; MCL1; Cell biology; Biology; Apoptosis; Programmed cell death; ATG8; Lipid-anchored protein; Endogeny; Downregulation and upregulation; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002773783,0.0003685278,0.0003801486,0.0003131539,0.0002732046,0.000546563,0.0002397154,0.000387596,0.003038167],"category_scores_gemma":[0.0003402642,0.0001623949,0.0003109999,0.0003539802,0.0003099618,0.0007378426,0.0003706255,0.0005806097,0.00069235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003586482,"about_ca_system_score_gemma":0.0002589106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004208979,"about_ca_topic_score_gemma":0.0004845765,"domain_scores_codex":[0.9995934,0.00008678167,0.00004629146,0.00005499134,0.0001095854,0.0001089119],"domain_scores_gemma":[0.9997315,0.00006446359,0.00006355388,0.0000430634,0.0000478966,0.00004955206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004628262,0.00006416503,0.001026872,0.00008552169,0.00001208537,0.00016172,0.00003178527,0.0001196243,0.9950293,0.0007281431,0.00007682062,0.002201068],"study_design_scores_gemma":[0.00007191835,0.0007772878,0.01549136,0.00001152058,0.00002911712,0.002803749,0.0001209858,0.001281094,0.9705476,0.0005500781,0.008298947,0.00001633951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841582,0.004729965,0.005123137,0.0001808828,0.00007057594,0.00003891624,0.0005852595,0.00007539657,0.005037628],"genre_scores_gemma":[0.993905,0.0008951869,0.001982943,0.00009010611,0.00001377855,0.00004219578,0.0006241972,0.00001599469,0.002430617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003038167,"threshold_uncertainty_score":0.01016366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007395454339791625,"score_gpt":0.2658676689877303,"score_spread":0.2584722146479387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}