{"id":"W2032352567","doi":"10.4161/auto.29639","title":"BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy","year":2014,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Australian Government","keywords":"Autophagy; BECN1; MCL1; Cell biology; Biology; Apoptosis; Programmed cell death; ATG8; Lipid-anchored protein; Endogeny; Downregulation and upregulation; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004737459,0.0003484687,0.0005650094,0.0001771847,0.0001926351,0.00005925902,0.0001221644,0.00023066,0.0003867384],"category_scores_gemma":[0.0002469249,0.0002967934,0.00009964959,0.0002964303,0.0001715251,0.0002095118,0.0001248747,0.000269387,0.0001667158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004867519,"about_ca_system_score_gemma":0.00009384948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000542967,"about_ca_topic_score_gemma":0.000006180033,"domain_scores_codex":[0.997955,0.0001523445,0.0003773482,0.0006709774,0.0003363501,0.0005080422],"domain_scores_gemma":[0.9985604,0.0001181527,0.00009943893,0.0005690168,0.0000727853,0.0005801666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.003060704,0.001821315,0.01734002,0.002181161,0.001359607,0.001760909,0.007018696,0.00002572786,0.4168291,0.09447008,0.005465263,0.4486674],"study_design_scores_gemma":[0.0129697,0.005844846,0.7669898,0.0006018966,0.0004655118,0.001061423,0.0001312836,0.003907813,0.1425629,0.0128426,0.05126961,0.001352673],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863845,0.001575678,0.0003112248,0.001384995,0.0003131421,0.00148692,0.00001157872,0.0003733394,0.008158624],"genre_scores_gemma":[0.9896352,0.00006986789,0.0009678509,0.001504084,0.0002488004,0.0001393166,0.00001968674,0.00007255625,0.007342666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7496497,"threshold_uncertainty_score":0.9999484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007395454339791625,"score_gpt":0.2658676689877303,"score_spread":0.2584722146479387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}