{"id":"W2032397718","doi":"10.1016/j.gde.2012.01.008","title":"Opening Pandora's Box — the new biology of driver mutations and clonal evolution in cancer as revealed by next generation sequencing","year":2012,"lang":"en","type":"review","venue":"Current Opinion in Genetics & Development","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; DNA sequencing; Somatic evolution in cancer; Genetics; Deep sequencing; Massive parallel sequencing; Computational biology; Cancer genome sequencing; Cancer; Chromatin; Genome; Gene; Genomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002978762,0.0002843039,0.0004605221,0.0001284862,0.00007113654,0.00003021688,0.000205336,0.0002412674,0.00001306079],"category_scores_gemma":[0.0000520166,0.0002456976,0.00006979991,0.0001856649,0.00007332624,0.000005673583,0.0002265709,0.0002017381,0.000002810999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003271926,"about_ca_system_score_gemma":0.001993627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001589034,"about_ca_topic_score_gemma":0.0002032638,"domain_scores_codex":[0.9982914,0.0001372627,0.0007516935,0.0004141483,0.0001201593,0.0002852918],"domain_scores_gemma":[0.999222,0.00004836098,0.0003586124,0.0002122567,0.00007115751,0.00008759573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009437478,0.00005781624,0.003130395,0.001244121,0.00007285718,1.396582e-7,0.0004458246,0.0001879996,0.002543473,0.000198749,0.001566478,0.9905427],"study_design_scores_gemma":[0.0004436549,0.00004596416,0.00058009,0.001597233,0.00007015328,0.000006462041,0.00003233818,0.00005957406,0.0004809854,0.00006495286,0.9962803,0.0003382614],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007438921,0.988681,0.001385535,0.00003067435,0.00167485,0.0007079285,0.00006753835,0.000002293559,0.00001124579],"genre_scores_gemma":[0.005574963,0.9907719,0.001159509,0.00001407511,0.0005292808,0.0002344329,0.001664826,0.00002743216,0.00002357024],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9947138,"threshold_uncertainty_score":0.9999995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1218968873226669,"score_gpt":0.3780913765837131,"score_spread":0.2561944892610463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}