{"id":"W2032419151","doi":"10.1080/15265161.2013.879960","title":"Predictive Genomic Testing of Children for Adult Onset Disorders: A Canadian Perspective","year":2014,"lang":"en","type":"letter","venue":"The American Journal of Bioethics","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Holland Bloorview Kids Rehabilitation Hospital; Hospital for Sick Children; University of Toronto; St Joseph's Health Centre","funders":"","keywords":"Medical genetics; Perspective (graphical); Genetic testing; Medicine; Predictive testing; Pediatrics; Family medicine; Gerontology; Psychology; Genetics; Internal medicine; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005077529,0.0007434287,0.001059071,0.001945998,0.005144626,0.003340694,0.002951758,0.02282519,0.005643905],"category_scores_gemma":[0.02306515,0.0005841706,0.001001191,0.001615041,0.005849293,0.002932126,0.001604858,0.02768375,0.001760051],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02989486,"about_ca_system_score_gemma":0.05044869,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6696836,"about_ca_topic_score_gemma":0.7646072,"domain_scores_codex":[0.9947743,0.0008526994,0.0005015898,0.0005704773,0.002516129,0.0007847397],"domain_scores_gemma":[0.9778806,0.006551144,0.0007587345,0.0003206227,0.009186635,0.005302266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000487116,0.00004407614,0.006042689,0.00009084118,0.00002527211,0.003523957,0.0004397435,0.0002666381,0.0003968442,0.008961335,0.9380869,0.04207304],"study_design_scores_gemma":[0.0001970727,0.0001089568,0.01762215,0.002659042,0.0001211241,0.01209035,0.002039011,0.001405215,0.0003642082,0.02607724,0.937091,0.0002246393],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0006129775,0.004963087,0.0001894989,0.9854741,0.003454175,0.000009756304,0.0001085931,0.00002604446,0.005161675],"genre_scores_gemma":[0.0199002,0.01396602,0.00154128,0.9364437,0.02233643,0.00002083304,0.0001712928,0.00003568672,0.005584578],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9701052,"threshold_uncertainty_score":0.6645234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586929671370388,"score_gpt":0.2701635931556438,"score_spread":0.2542942964419399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}