{"id":"W2032435199","doi":"10.1074/jbc.m708763200","title":"The Regulated Cell Surface Zymogen Activation of the Proprotein Convertase PC5A Directs the Processing of Its Secretory Substrates","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Proprotein Convertases; Furin; Zymogen; Endoplasmic reticulum; Proprotein convertase; Chemistry; C3-convertase; Cell biology; Biochemistry; Golgi apparatus; Protein precursor; Complement system; Enzyme; Biology; Alternative complement pathway; Antibody; Immunology; Lipoprotein; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008009833,0.0001168213,0.0001537703,0.000005569492,0.0001134408,0.00001005656,0.0003278343,0.0002235697,0.00001492989],"category_scores_gemma":[0.0001252516,0.00005103602,0.0001665018,0.00009685408,0.0002234832,0.000005151059,0.00002631826,0.0002169842,1.472383e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001366343,"about_ca_system_score_gemma":0.0001109081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002969564,"about_ca_topic_score_gemma":0.000002034795,"domain_scores_codex":[0.9990112,0.00005584921,0.0004633442,0.0001182967,0.0001959797,0.0001553612],"domain_scores_gemma":[0.9987366,0.00005120749,0.0006798459,0.0001797259,0.0003085618,0.00004402558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003601829,0.0000607732,0.003130223,0.0000701539,0.00002735841,0.000001648922,0.00004626184,0.00004688665,0.9958912,0.000001993055,0.00001410903,0.0003491691],"study_design_scores_gemma":[0.0002728601,0.0001117771,0.007089486,0.00005563557,0.0000203924,0.00001568879,0.0002045307,0.00002687374,0.9908213,0.00002803373,0.00128408,0.000069325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963073,0.002820933,0.000292162,0.0001379647,0.00004108511,0.0001384366,0.000005138284,0.000002431716,0.0002545349],"genre_scores_gemma":[0.9993401,0.0002459103,0.00004133555,0.00001782739,0.0001085077,8.983357e-7,0.00004479337,0.000006673459,0.0001939873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005069923,"threshold_uncertainty_score":0.2081189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01251147724504603,"score_gpt":0.2189589260864964,"score_spread":0.2064474488414503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}