{"id":"W2032456556","doi":"10.3390/ph4101381","title":"Lipothioureas as Lipids for Gene Transfection: A Review","year":2011,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Transfection; Thiourea; In vivo; In vitro; Linker; Chemistry; Biochemistry; Cell; DNA; Gene; Cell biology; Computational biology; Pharmacology; Biology; Biotechnology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004255855,0.0004922071,0.001160419,0.00006232961,0.00007446959,0.0000234829,0.0004499642,0.0004387307,0.0005311246],"category_scores_gemma":[0.0001224065,0.0004064485,0.00114422,0.0001270293,0.00007076753,0.000003802215,0.00007621247,0.0002416744,0.0004273014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000207988,"about_ca_system_score_gemma":0.0002689393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004258306,"about_ca_topic_score_gemma":0.000001413497,"domain_scores_codex":[0.9979953,0.0001789895,0.0006147358,0.0006846527,0.0001111629,0.0004151871],"domain_scores_gemma":[0.9989114,0.00004295027,0.0001530893,0.0005211883,0.0001442499,0.0002271398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000357422,0.00008646965,2.355518e-7,0.02957527,0.0005005667,0.000003321642,0.000005779637,3.271256e-8,0.0005198711,0.00006678734,0.02692195,0.942284],"study_design_scores_gemma":[0.0002251126,0.0002979375,5.702168e-8,0.00852294,0.002117121,0.0001833135,9.344407e-7,5.170172e-7,0.003609012,0.00003714417,0.9845453,0.0004605959],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000003454694,0.9941599,0.0007656562,0.00007437003,0.0006232022,0.00174921,0.000149146,0.00002689042,0.002448172],"genre_scores_gemma":[0.000005843855,0.992442,0.0001994779,0.002114902,0.001327255,0.000977697,0.0005354701,0.00008577902,0.002311551],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9576234,"threshold_uncertainty_score":0.9998387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1456258539701797,"score_gpt":0.444849601664675,"score_spread":0.2992237476944953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}