{"id":"W2032466777","doi":"10.1038/ni1170","title":"Crystal structure of a soluble CD28-Fab complex","year":2005,"lang":"en","type":"article","venue":"Nature Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":179,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Garron Family Cancer Centre","keywords":"CD28; CD86; CD80; Receptor; Cell biology; T cell; Antibody; Antigen; Molecular biology; Chemistry; Biology; Biochemistry; Immune system; CD40; Immunology; Cytotoxic T cell; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878014,0.0005571051,0.0007407202,0.000231346,0.0007192913,0.00100659,0.001107222,0.0006443408,0.003499484],"category_scores_gemma":[0.0005238149,0.0002558825,0.0002070037,0.0003273395,0.0003300778,0.0003801523,0.0003851363,0.002078235,0.0005747739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001958271,"about_ca_system_score_gemma":0.001451937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01456477,"about_ca_topic_score_gemma":0.01096479,"domain_scores_codex":[0.9998506,0.00001254763,0.000004955865,0.0000315376,0.00006038498,0.00003987027],"domain_scores_gemma":[0.9998166,0.0000536739,0.00002298617,0.000007574045,0.00003419222,0.00006492721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005308457,0.001852051,0.01075248,0.001595593,0.0006572992,0.008869749,0.00137214,0.01981583,0.7889724,0.02111026,0.08911192,0.05058187],"study_design_scores_gemma":[0.004746697,0.001665606,0.07274169,0.0003482618,0.000893064,0.01034941,0.003088992,0.1652458,0.5267413,0.01195943,0.2017938,0.0004260905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694343,0.007107276,0.003461843,0.00293381,0.0005315743,0.00006312465,0.003964277,0.0005557886,0.01194793],"genre_scores_gemma":[0.9685148,0.003680146,0.004282154,0.0006723032,0.00008123767,0.00004618593,0.01127714,0.00008055099,0.01136537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01456477,"threshold_uncertainty_score":0.02895999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007744190886582556,"score_gpt":0.2316669928505454,"score_spread":0.2239228019639628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}