{"id":"W2032475954","doi":"10.1371/journal.pgen.1002057","title":"The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Terry Fox Foundation; National Institutes of Health; National Human Genome Research Institute; Michael Smith Health Research BC","keywords":"Biology; Genetics; Candidate gene; Gene; Phenotype; Genetic screen; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257104,0.0004828585,0.000480796,0.001863474,0.0003370577,0.0004844509,0.0001766764,0.0001936948,0.002719178],"category_scores_gemma":[0.0002495892,0.0001191251,0.0005510004,0.002096966,0.0001143658,0.0001671973,0.0004093822,0.0002221652,0.001284533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002224403,"about_ca_system_score_gemma":0.0003496255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310649,"about_ca_topic_score_gemma":0.002923656,"domain_scores_codex":[0.999862,0.000006321617,0.00001207444,0.00005424533,0.00004381089,0.00002159359],"domain_scores_gemma":[0.9998305,0.00003807826,0.00003901128,0.00002282225,0.00003025857,0.00003932395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008764042,0.00006180091,0.07570057,0.0009478453,0.0001946777,0.001332265,0.0001724325,0.001735122,0.8551779,0.0007241697,0.00351025,0.05956648],"study_design_scores_gemma":[0.0000821682,0.000376632,0.726752,0.0001870474,0.0005622224,0.004488812,0.0003776041,0.006667436,0.1900833,0.001780929,0.06856276,0.00007912235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9138167,0.003905113,0.005915534,0.00008693658,0.00001924953,0.00004335525,0.07321909,0.0007456237,0.002248309],"genre_scores_gemma":[0.7837835,0.004934263,0.0146887,0.0001713726,0.00001834684,0.0001133692,0.1927376,0.0002612743,0.003291646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002719178,"threshold_uncertainty_score":0.009096503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09228640209206362,"score_gpt":0.2359484762277279,"score_spread":0.1436620741356643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}