{"id":"W2032478741","doi":"10.1021/jm900639u","title":"Efficacious 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors in the Diet-Induced Obesity Mouse Model","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"11β-hydroxysteroid dehydrogenase type 1; Chemistry; Endocrinology; Cortisone; Internal medicine; In vivo; Ex vivo; Pharmacokinetics; Dehydrogenase; Glucocorticoid; Enzyme; Diabetes mellitus; Type 2 diabetes; Obesity; Pharmacology; Insulin; Glucocorticoid receptor; Insulin resistance; Receptor; Biochemistry; In vitro; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002150708,0.0005058899,0.0005105851,0.0005007791,0.0001680229,0.000226608,0.0003175442,0.0002730398,0.001137361],"category_scores_gemma":[0.0001128671,0.0002180006,0.0002310537,0.0003141779,0.0002040247,0.0002584084,0.0001117001,0.0008111932,0.0002621931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267652,"about_ca_system_score_gemma":0.0003508081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006859056,"about_ca_topic_score_gemma":0.002197008,"domain_scores_codex":[0.9999095,0.00002060307,0.000006350087,0.00001490718,0.00002231523,0.00002641302],"domain_scores_gemma":[0.9999342,0.000008708925,0.00001870778,0.000006887618,0.000009378002,0.00002201739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001225566,0.0006631555,0.0001948923,0.0001041798,0.00002798982,0.0001328843,0.00002403042,0.0004897372,0.9879723,0.0003365958,0.0003301942,0.008498488],"study_design_scores_gemma":[0.0006777887,0.008244481,0.002648539,0.0000225515,0.00009952446,0.000333065,0.00002239542,0.001377962,0.9805263,0.0001386467,0.005893669,0.00001516482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807652,0.006798299,0.006104157,0.000378173,0.0001047957,0.0002421433,0.00131997,0.0003371742,0.003950235],"genre_scores_gemma":[0.974387,0.009888152,0.007376993,0.0002408197,0.00005171654,0.0002169738,0.001924089,0.0000405475,0.005873761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137361,"threshold_uncertainty_score":0.003804803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02366676940846251,"score_gpt":0.2784149698439411,"score_spread":0.2547482004354786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}