{"id":"W2032488514","doi":"10.1016/j.jpba.2011.06.013","title":"A bioanalytical investigation on the exquisitely strong in vitro potency of the EGFR–DNA targeting type II combi-molecule ZR2003 and its mitigated in vivo antitumour activity","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Regional Health Centre; McGill University; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; Jewish General Hospital","keywords":"In vivo; Chemistry; In vitro; Potency; Epidermal growth factor; Cytotoxicity; Epidermal growth factor receptor; Pharmacology; Cancer research; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006096955,0.0001183648,0.0002709333,0.0001805861,0.00006143027,0.00001093491,0.0001756121,0.0001117483,0.00007149566],"category_scores_gemma":[0.0002517544,0.00006426806,0.000133404,0.0007067914,0.0002891709,0.00001156885,0.00012164,0.0002875979,4.025636e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001208685,"about_ca_system_score_gemma":0.00005957008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003762999,"about_ca_topic_score_gemma":0.0000138813,"domain_scores_codex":[0.9987909,0.0002132184,0.0003993739,0.0001722922,0.0002452814,0.0001789407],"domain_scores_gemma":[0.9994391,0.00004300063,0.0001754739,0.00008654113,0.0001142992,0.0001415427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003873534,0.000216867,0.008359315,0.00001343598,0.0002563977,0.00001528728,0.00008454765,0.000003397182,0.989847,0.00004181414,0.00008519299,0.000689411],"study_design_scores_gemma":[0.0005719966,0.0004085212,0.02029794,0.00004665966,0.0003148449,0.00001371274,0.0001233846,0.005626829,0.9723057,0.00006760215,0.0001244177,0.00009843853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978114,0.0004667422,0.00005334042,0.001476221,0.00004730929,0.00006105046,0.000009300011,9.824417e-7,0.00007365726],"genre_scores_gemma":[0.999225,0.0003124704,0.00004930746,0.0003377195,0.00004339579,8.271792e-7,0.000002826526,0.000004023562,0.00002448204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01754133,"threshold_uncertainty_score":0.2620775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04232349634099517,"score_gpt":0.2860667466386201,"score_spread":0.2437432502976249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}