{"id":"W2032531505","doi":"10.1158/1078-0432.ccr-07-4049","title":"Radiation-Mediated Up-Regulation of Gene Expression from Replication-Defective Adenoviral Vectors: Implications for Sodium Iodide Symporter Gene Therapy","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Sodium-iodide symporter; Green fluorescent protein; Genetic enhancement; Cancer research; Multiplicity of infection; Transgene; Adenoviridae; In vivo; Viral vector; Molecular biology; Biology; Gene expression; Viral replication; Symporter; Chemistry; Virology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001718608,0.0001819912,0.0003137779,0.0001415511,0.0003391138,0.00002090469,0.0005346629,0.000353253,0.0002071775],"category_scores_gemma":[0.001082896,0.0001690727,0.0002372864,0.0003522571,0.0005241119,0.00001577698,0.0001071811,0.0003234771,0.00002397292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001020154,"about_ca_system_score_gemma":0.0009551229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002350279,"about_ca_topic_score_gemma":0.00006083478,"domain_scores_codex":[0.9967378,0.0006097716,0.0007335967,0.0009698924,0.0004850147,0.0004639667],"domain_scores_gemma":[0.9962385,0.0007189076,0.000247629,0.001384523,0.001193765,0.0002167212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003845763,0.0002294071,0.04872708,0.000007280882,0.0001290696,2.582321e-7,0.0001018941,0.000040493,0.9302037,0.000007548678,0.005944768,0.01076278],"study_design_scores_gemma":[0.002245188,0.001675238,0.1897931,0.00001179275,0.000007852668,9.797516e-7,0.00001619045,0.00009623214,0.8001022,0.0003524089,0.005534948,0.0001638641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923221,0.003363318,0.001044096,0.001009848,0.0001619667,0.00138001,0.0006288768,0.00002233689,0.00006744403],"genre_scores_gemma":[0.9889856,0.00577138,0.0004484214,0.0001886504,0.001227551,0.001262923,0.001738438,0.00005976876,0.0003172476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.141066,"threshold_uncertainty_score":0.6894584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.155156613892083,"score_gpt":0.4691225742903704,"score_spread":0.3139659603982873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}