{"id":"W2032611676","doi":"10.1371/journal.pone.0050536","title":"MicroRNA 218 Mediates the Effects of Tbx5a Over-Expression on Zebrafish Heart Development","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; University of California, San Francisco; Regione Toscana; Institute of Genetics; Università di Pisa","keywords":"Zebrafish; Heart development; microRNA; Haploinsufficiency; Biology; Transcription factor; Regulation of gene expression; Gene; Gene expression; Genetics; Cell biology; Heart disease; Gene regulatory network; TBX1; Bioinformatics; Phenotype; Medicine; Promoter; Pathology; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009984925,0.0004283091,0.0002298025,0.0002054924,0.0001886263,0.000199998,0.0001665806,0.0002709205,0.001771133],"category_scores_gemma":[0.0001350445,0.0002162026,0.0002689127,0.00005949669,0.0002278264,0.0001087751,0.0002896666,0.0003205161,0.000483283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873024,"about_ca_system_score_gemma":0.0002835566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009981,"about_ca_topic_score_gemma":0.001602154,"domain_scores_codex":[0.9998742,0.00001528276,0.00001246186,0.00003286504,0.00003783786,0.00002734776],"domain_scores_gemma":[0.9999082,0.00001729579,0.00003526276,0.000007150461,0.000006263733,0.00002569017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004334921,0.00000412631,0.00009155725,0.00001851748,0.000001594382,0.00004517145,0.000004677016,0.00002506999,0.9994277,0.00003514727,0.00001093942,0.000292094],"study_design_scores_gemma":[0.000008980479,0.0001327817,0.004960388,0.000004669068,0.00001170034,0.0001360087,0.00001146444,0.0005919798,0.9928374,0.00002372512,0.001276807,0.000004014848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940895,0.001295549,0.001842693,0.00007653267,0.00002279366,0.00002203372,0.0003095975,0.0001272076,0.00221411],"genre_scores_gemma":[0.9953156,0.0005643375,0.001509019,0.00005117355,0.000005082931,0.00002653621,0.0003195027,0.00003142178,0.002177351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001771133,"threshold_uncertainty_score":0.005925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998637196332601,"score_gpt":0.2551351008370627,"score_spread":0.2351487288737367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}