{"id":"W2032618723","doi":"10.1073/pnas.1317118110","title":"Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Heart, Lung, and Blood Institute","keywords":"Antibody; Proto-Oncogene Proteins c-kit; Tyrosine kinase; Epitope; Receptor tyrosine kinase; Cancer research; Biology; Monoclonal antibody; Melanoma; Affinity maturation; Molecular biology; Receptor; Immunology; Cell biology; Biochemistry; Stem cell factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009250092,0.0002790284,0.0001325946,0.0001210798,0.0002205839,0.0002809356,0.0004220498,0.0002960133,0.00123071],"category_scores_gemma":[0.0001203211,0.0001542751,0.000212662,0.00005222905,0.0002404456,0.0001398343,0.0002176297,0.0004927194,0.0003606301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004401575,"about_ca_system_score_gemma":0.0003812612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006827852,"about_ca_topic_score_gemma":0.0007002662,"domain_scores_codex":[0.9999317,0.00001086266,0.000005373182,0.0000103728,0.00002273996,0.00001894978],"domain_scores_gemma":[0.9999626,0.000007176209,0.00001044034,0.000002586253,0.000006235108,0.00001099643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000168918,0.00008462867,0.0006496982,0.00003542862,0.00001134806,0.0002543325,0.00001514023,0.001212884,0.9918272,0.002940429,0.000192358,0.002607526],"study_design_scores_gemma":[0.0001181257,0.0004991144,0.002926086,0.00001145466,0.00004213706,0.00087362,0.00003593476,0.01041301,0.9778326,0.0007970867,0.00644034,0.00001049222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757527,0.0008576588,0.01398375,0.0004489424,0.00007185093,0.00007859504,0.0001681049,0.0001424898,0.008495877],"genre_scores_gemma":[0.9956198,0.0003491855,0.002512882,0.000185132,0.000007659813,0.00001895706,0.0001839706,0.00001341335,0.001108945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123071,"threshold_uncertainty_score":0.004117131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04566615484815464,"score_gpt":0.3138079889627599,"score_spread":0.2681418341146052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}