{"id":"W2032621158","doi":"10.1016/j.nbd.2010.10.016","title":"Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration","year":2010,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; Feldstein Medical Foundation; National Institute of Neurological Disorders and Stroke; University of Calgary; Shriners Hospitals for Children; National Institutes of Health","keywords":"Purkinje cell; Cerebellum; Biology; Apoptosis-inducing factor; Cell biology; Mitochondrion; mitochondrial fusion; Neurodegeneration; Neuroscience; Apoptosis; MFN1; Pathology; Programmed cell death; Caspase; Medicine; Genetics; Mitochondrial DNA; Disease; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001596377,0.0005441782,0.0005677376,0.0007801058,0.0002500437,0.0005135997,0.0005204912,0.0005977534,0.001475405],"category_scores_gemma":[0.0003034779,0.0003736503,0.0002247127,0.0003638416,0.0006145443,0.0003756153,0.0003166639,0.0008471826,0.0003426894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006107908,"about_ca_system_score_gemma":0.0002797967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001229123,"about_ca_topic_score_gemma":0.001833994,"domain_scores_codex":[0.9996678,0.00003348563,0.00005623023,0.00008134513,0.00008624644,0.00007484572],"domain_scores_gemma":[0.9993748,0.0001166617,0.0002423054,0.00007485269,0.00002908229,0.0001622803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001488175,0.00002958884,0.0003313131,0.00002062146,0.000009885893,0.000369986,0.00001476172,0.00008203986,0.9982172,0.0001334045,0.00002875325,0.0006136207],"study_design_scores_gemma":[0.00004182738,0.0001830717,0.009073437,0.000006577726,0.00003414792,0.001982808,0.00005933818,0.0009394644,0.9868412,0.0001409612,0.0006885034,0.000008668848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955597,0.0007357062,0.002303791,0.00007978015,0.00002529755,0.00001397233,0.0003670512,0.0001612847,0.0007533722],"genre_scores_gemma":[0.9967301,0.0002382356,0.001340611,0.00001831567,0.000005766295,0.0000127863,0.0002150964,0.00003884408,0.001400135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475405,"threshold_uncertainty_score":0.004935682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086948330736856,"score_gpt":0.2319852328013484,"score_spread":0.2211157494939799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}