{"id":"W2032647451","doi":"10.1371/journal.pone.0056387","title":"Calreticulin Induces Dilated Cardiomyopathy","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba; University of Toronto; University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Calreticulin; Endoplasmic reticulum; Calsequestrin; Biology; Ryanodine receptor; Cell biology; Connexin; Heart failure; Internal medicine; Cardiomyopathy; Ryanodine receptor 2; Phospholamban; Endocrinology; Gap junction; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001769063,0.0005151891,0.0003748165,0.0003468503,0.0001969058,0.0001705772,0.0002174613,0.0004683495,0.003855383],"category_scores_gemma":[0.0001347437,0.0001436268,0.0002431774,0.0001943467,0.0003885486,0.0001630007,0.0003866981,0.0006561267,0.0005574912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003110675,"about_ca_system_score_gemma":0.0001758151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001424259,"about_ca_topic_score_gemma":0.0002365536,"domain_scores_codex":[0.999836,0.00003370003,0.00002218432,0.00004728668,0.00003098186,0.00002989407],"domain_scores_gemma":[0.9997255,0.00005334156,0.0001003387,0.00002819809,0.00001701335,0.00007556145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004134243,0.0001549936,0.000386457,0.00008750252,0.000007009417,0.0004164267,0.0000129698,0.00004074495,0.9968517,0.0001180617,0.00008770863,0.001423009],"study_design_scores_gemma":[0.0003281331,0.002352692,0.02976214,0.00004327766,0.00008884117,0.003364645,0.00007179806,0.001205973,0.955074,0.0002304435,0.007465063,0.00001292572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933057,0.001291997,0.002241006,0.0002293797,0.0001279147,0.00008989888,0.0005493187,0.0001867357,0.0019781],"genre_scores_gemma":[0.9898494,0.001095417,0.001625641,0.0002404188,0.00004317948,0.0001270163,0.0007879753,0.00005553552,0.006175308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003855383,"threshold_uncertainty_score":0.01289755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668508610043803,"score_gpt":0.2052645569123905,"score_spread":0.1885794708119524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}