{"id":"W2032687678","doi":"10.1210/me.2010-0422","title":"A Pituitary-Specific Enhancer of the POMC Gene with Preferential Activity in Corticotrope Cells","year":2010,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Cancer Institute; Université de Montréal; Canadian Institutes of Health Research; Institut de Recherche Clinique De Montréal","keywords":"Enhancer; Biology; Palindromic sequence; Transcription (linguistics); Proopiomelanocortin; Regulatory sequence; Gene; Corticotropic cell; Enhancer RNAs; Molecular biology; Regulation of gene expression; Gene expression; Genetics; Anterior pituitary; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003662457,0.000196659,0.0003759679,0.00013543,0.00003525548,0.000005754269,0.0002051219,0.0001225047,0.0001541349],"category_scores_gemma":[0.00002320968,0.0001298672,0.0001101263,0.0002616857,0.0002687584,0.00004659475,0.0001138461,0.0006667515,0.0000205602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003861907,"about_ca_system_score_gemma":0.0001394956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001777231,"about_ca_topic_score_gemma":0.0001255373,"domain_scores_codex":[0.998628,0.00007680651,0.0002652367,0.0003414724,0.000239676,0.0004488211],"domain_scores_gemma":[0.99905,0.00002345368,0.0001160577,0.0006440538,0.00008508688,0.0000813913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003714407,0.0002337877,0.01270939,0.00002096498,0.00006063296,0.0001505434,0.00008909363,0.000006526554,0.9840854,0.0005235138,0.00006938704,0.001679362],"study_design_scores_gemma":[0.001514391,0.0003422163,0.1759419,0.0000124457,0.0000487485,0.0001033496,0.00001096953,0.0000137721,0.8202838,0.00004909265,0.001571052,0.0001082378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964699,0.0001811699,0.0005684608,0.0003172817,0.000405616,0.0004534379,0.000007235984,0.00002522494,0.001571676],"genre_scores_gemma":[0.9990916,0.00008064407,0.0004726551,0.0001402345,0.00005087764,0.00003109726,0.000005638878,0.00002929186,0.00009796546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1638015,"threshold_uncertainty_score":0.529583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007155696282756418,"score_gpt":0.2170952327183731,"score_spread":0.2099395364356167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}