{"id":"W2032690812","doi":"10.3390/ph3072111","title":"Protein Kinases as Drug Development Targets for Heart Disease Therapy","year":2010,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Kinase; ASK1; Protein kinase A; Signal transduction; Medicine; Protein kinase C; MAPK/ERK pathway; c-Raf; Cell biology; Cyclin-dependent kinase 2; Cardiac function curve; Biology; Internal medicine; Heart failure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005176088,0.0009766011,0.001476825,0.002088571,0.0002963872,0.000849414,0.0007720524,0.001014117,0.005738631],"category_scores_gemma":[0.0003867016,0.0003032578,0.0004364979,0.001779557,0.0005076278,0.001397207,0.0006383795,0.00203385,0.004768929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005967937,"about_ca_system_score_gemma":0.000657853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000707638,"about_ca_topic_score_gemma":0.001762944,"domain_scores_codex":[0.9998467,0.00002637738,0.00001574584,0.00002782326,0.00006463854,0.00001877243],"domain_scores_gemma":[0.9998379,0.0000609711,0.00002689775,0.000007888707,0.00004450152,0.00002189584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001295613,0.0002011267,0.0001334785,0.006214617,0.0000966494,0.0003066843,0.00005690353,0.000691857,0.005140868,0.006334621,0.03705024,0.9436436],"study_design_scores_gemma":[0.00005554661,0.0001252716,0.0004420514,0.000911744,0.00007190563,0.0007263458,0.0000284828,0.000136799,0.0008333375,0.001914114,0.9947414,0.00001298421],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003740888,0.9942688,0.0003991106,0.0003930586,0.0003176426,0.00001873217,0.00004275488,0.00002546421,0.004160349],"genre_scores_gemma":[0.001506892,0.9942405,0.000600464,0.0004108921,0.0001733506,0.00001924972,0.0000683761,0.00000425389,0.002975987],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005738631,"threshold_uncertainty_score":0.0191977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07609218102744422,"score_gpt":0.4302942225352379,"score_spread":0.3542020415077937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}