{"id":"W2032690812","doi":"10.3390/ph3072111","title":"Protein Kinases as Drug Development Targets for Heart Disease Therapy","year":2010,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Kinase; ASK1; Protein kinase A; Signal transduction; Medicine; Protein kinase C; MAPK/ERK pathway; c-Raf; Cell biology; Cyclin-dependent kinase 2; Cardiac function curve; Biology; Internal medicine; Heart failure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003615858,0.0005228829,0.001802261,0.0001232155,0.0001744549,0.00002041342,0.000131782,0.0002474645,0.000361258],"category_scores_gemma":[0.0002648943,0.0003727842,0.0008732515,0.0001406214,0.0001365024,0.0000381624,0.0000560851,0.0008671955,0.0005056289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007628786,"about_ca_system_score_gemma":0.001381166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.768261e-7,"about_ca_topic_score_gemma":1.508446e-7,"domain_scores_codex":[0.99785,0.0001722119,0.0005332974,0.0006000681,0.0002394344,0.0006049949],"domain_scores_gemma":[0.9984446,0.0003260285,0.0001357515,0.0003980093,0.0001037001,0.0005919769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005014612,0.000283357,0.000001255254,0.009347944,0.0003690368,0.000169586,0.00002259945,5.272482e-8,0.0005359667,0.0002444071,0.005150176,0.9833742],"study_design_scores_gemma":[0.0008529504,0.00007546548,0.000005997121,0.002815397,0.0007756679,0.0001070466,9.394608e-7,0.000001383678,0.002803032,0.0002392966,0.9919293,0.0003935055],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004310678,0.9916183,0.00001245231,0.001130321,0.0003383969,0.006083264,0.00006497784,0.0001157629,0.0002055098],"genre_scores_gemma":[0.0001359864,0.9886213,0.0008280337,0.002342367,0.001213992,0.00373681,0.0004092992,0.000103998,0.002608236],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9867792,"threshold_uncertainty_score":0.9998724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07609218102744422,"score_gpt":0.4302942225352379,"score_spread":0.3542020415077937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}