{"id":"W2032702320","doi":"10.1016/j.clinthera.2012.03.060","title":"Efficacy and Tolerability of a 20-mg Dose of Methylphenidate for the Treatment of Daytime Sleepiness in Adult Patients With Myotonic Dystrophy Type 1: A 2-Center, Randomized, Double-Blind, Placebo-Controlled, 3-Week Crossover Trial","year":2012,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cégep de Jonquière; Hôpital de l'Enfant-Jésus; Centre hospitalier universitaire de Québec","funders":"Centre Hospitalier Universitaire de Québec","keywords":"Tolerability; Medicine; Epworth Sleepiness Scale; Methylphenidate; Placebo; Crossover study; Excessive daytime sleepiness; Physical therapy; Adverse effect; Internal medicine; Sleep disorder; Psychiatry; Attention deficit hyperactivity disorder; Polysomnography; Insomnia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001936144,0.002268995,0.004257978,0.0005613409,0.0007516114,0.0008922125,0.001455903,0.003299879,0.004953668],"category_scores_gemma":[0.001985773,0.001312394,0.001966487,0.0004054522,0.001772468,0.0018474,0.0005476017,0.003418124,0.001101743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007916349,"about_ca_system_score_gemma":0.001114381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001371379,"about_ca_topic_score_gemma":0.00256048,"domain_scores_codex":[0.9992412,0.0003071996,0.00007365946,0.0001854616,0.00006682643,0.0001256806],"domain_scores_gemma":[0.998854,0.0002648506,0.0002144619,0.0001093943,0.00008418768,0.0004731064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9790276,0.01004426,0.00051413,0.0002260627,0.0004226092,0.00003884213,0.00006480642,0.0001770384,0.002904286,0.00003521297,0.0003083246,0.006236914],"study_design_scores_gemma":[0.916617,0.0802808,0.002117517,0.0000106911,0.0001901598,0.00002060672,0.00001778024,0.0002684577,0.0002909976,0.00004107237,0.0001286285,0.00001636341],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940388,0.001631023,0.0003640858,0.0003280107,0.0002986805,0.001817493,0.0006233876,0.00008556621,0.0008128608],"genre_scores_gemma":[0.9912005,0.001365275,0.001114603,0.000901248,0.0005230908,0.002437802,0.0008869472,0.00003068939,0.001539915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004953668,"threshold_uncertainty_score":0.0165717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1306469501111931,"score_gpt":0.3884028703296902,"score_spread":0.2577559202184971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}