{"id":"W2032702320","doi":"10.1016/j.clinthera.2012.03.060","title":"Efficacy and Tolerability of a 20-mg Dose of Methylphenidate for the Treatment of Daytime Sleepiness in Adult Patients With Myotonic Dystrophy Type 1: A 2-Center, Randomized, Double-Blind, Placebo-Controlled, 3-Week Crossover Trial","year":2012,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cégep de Jonquière; Hôpital de l'Enfant-Jésus; Centre hospitalier universitaire de Québec","funders":"Centre Hospitalier Universitaire de Québec","keywords":"Tolerability; Medicine; Epworth Sleepiness Scale; Methylphenidate; Placebo; Crossover study; Excessive daytime sleepiness; Physical therapy; Adverse effect; Internal medicine; Sleep disorder; Psychiatry; Attention deficit hyperactivity disorder; Polysomnography; Insomnia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008141006,0.0002857692,0.001490918,0.00006120834,0.00005518371,0.00001770874,0.0002649112,0.0001040874,0.00001347288],"category_scores_gemma":[0.001098888,0.0001525256,0.0003809566,0.0002381795,0.000982692,0.00007656461,0.00005099774,0.0001135678,9.607373e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002283646,"about_ca_system_score_gemma":0.0001074215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009631163,"about_ca_topic_score_gemma":0.000005437082,"domain_scores_codex":[0.9964618,0.0009937697,0.001460814,0.0004251707,0.0003369511,0.0003214582],"domain_scores_gemma":[0.9898576,0.008298354,0.0008242901,0.0005683627,0.0003401992,0.0001112085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9757815,0.01218105,0.006374991,0.00003657441,0.0002710188,2.277747e-7,0.000334598,0.0001728956,0.002077744,0.0001189653,0.000001005261,0.002649401],"study_design_scores_gemma":[0.9623644,0.005103487,0.003299303,0.00002599939,0.0006349755,2.36169e-7,0.00001311025,0.000945301,0.02733675,0.00006263145,0.00007411759,0.0001397027],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903966,0.0003724336,0.0001412089,0.00007965853,0.0004619805,0.008382706,0.0001421328,0.000007694664,0.00001560201],"genre_scores_gemma":[0.9985766,0.0005238655,0.000246688,0.0001284978,0.00007389117,0.0003896665,0.000008424985,0.00002732345,0.00002499273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02525901,"threshold_uncertainty_score":0.6219811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1306469501111931,"score_gpt":0.3884028703296902,"score_spread":0.2577559202184971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}