{"id":"W2032703343","doi":"10.1016/j.gene.2014.08.057","title":"The functional VNTR of IGH enhancer HS1.2 associates with human longevity and interacts with TNFA promoter diplotype in a population of Central Italy","year":2014,"lang":"en","type":"article","venue":"Gene","topic":"Diet and metabolism studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute","funders":"","keywords":"Biology; Longevity; Genetics; Enhancer; Promoter; Population; Evolutionary biology; Gene; Transcription factor; Gene expression; Demography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001366433,0.00006676604,0.000192077,0.00002675341,0.00003650682,0.000004656275,0.00001889014,0.00002163723,0.000008085758],"category_scores_gemma":[0.00004360966,0.00003528731,0.00001656047,0.00006255792,0.00006227422,0.00004105696,0.00001743621,0.00005330441,4.493687e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001362453,"about_ca_system_score_gemma":0.0000132353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001053958,"about_ca_topic_score_gemma":0.0008155321,"domain_scores_codex":[0.9994964,0.00002309028,0.0001300508,0.00009453351,0.0001420524,0.0001138614],"domain_scores_gemma":[0.9996893,0.00003241349,0.00009745069,0.00008090299,0.00007564838,0.00002424798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004900712,0.0001119936,0.979749,0.00005410822,0.0001196358,7.884388e-7,0.0008776005,0.000004863678,0.0150408,0.0002027748,0.0000515725,0.003296823],"study_design_scores_gemma":[0.0008866671,0.0003094,0.9888524,0.00008588046,0.00007396072,0.000001225366,0.00004611494,0.00001362124,0.00943267,0.0001087999,0.0001481402,0.0000410613],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987931,0.0003295705,0.00002725332,0.000177436,0.0000549906,0.0001475125,0.000002217123,0.000005455997,0.0004625126],"genre_scores_gemma":[0.9995002,0.00003702792,0.0001076714,0.00001830989,0.0000751457,0.000007325725,0.00001270871,0.000006904432,0.0002347798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009103488,"threshold_uncertainty_score":0.1438975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009946152366111127,"score_gpt":0.2418396367627187,"score_spread":0.2318934843966076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}