{"id":"W2032713794","doi":"10.1097/01.jto.0000283530.57729.23","title":"P2-066: Analysis of EGFR gene copy number, EGFR mutations, KRAS mutations and EGFR expression in a cohort of non-small cell lung cancer patients treated with epidermal growth factor tyrosine kinase inhibitors at a North American institution.","year":2007,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Cancer Foundation; University of Calgary","funders":"","keywords":"KRAS; Erlotinib; CISH; Gefitinib; Medicine; Lung cancer; Epidermal growth factor receptor; Chromogenic in situ hybridization; Cancer research; Population; Tyrosine kinase; Fluorescence in situ hybridization; Neuroblastoma RAS viral oncogene homolog; Gene duplication; EGFR inhibitors; Oncology; Cancer; Internal medicine; Gene; Biology; Gene expression; In situ hybridization; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002199037,0.0002092321,0.0003227484,0.0004534792,0.0004445212,0.0004650295,0.0003386831,0.0003626127,0.001496376],"category_scores_gemma":[0.0007305796,0.0002800261,0.0002417728,0.0007776305,0.0002680585,0.0003529,0.0003506854,0.0004993846,0.0003248859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002530591,"about_ca_system_score_gemma":0.0003423873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004629639,"about_ca_topic_score_gemma":0.006794577,"domain_scores_codex":[0.9998004,0.00003864161,0.00001500307,0.0000619085,0.00004485725,0.00003926184],"domain_scores_gemma":[0.9994457,0.00008727275,0.0001818262,0.00003787192,0.00004978464,0.0001975329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004516577,0.00006879504,0.9966595,0.000003961125,0.00003424089,0.0002626932,0.00004992008,0.00004099666,0.001148963,0.0000095012,0.0002385125,0.001031316],"study_design_scores_gemma":[0.00001589053,0.000156459,0.9981502,0.000001358914,0.00001864037,0.001087854,0.0001256076,0.0001317574,0.0001414636,0.000010362,0.0001574856,0.000002817242],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995184,0.00003899884,0.00001536499,0.00001850521,0.000001552269,0.00000277279,0.0002679522,0.00000186159,0.0001345475],"genre_scores_gemma":[0.9990658,0.00003916967,0.00005172458,0.00002817999,0.000006929264,0.000006626557,0.0006240609,0.000002986738,0.0001746143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004629639,"threshold_uncertainty_score":0.009205401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009157552079469352,"score_gpt":0.3628220872885492,"score_spread":0.3536645352090799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}