{"id":"W2032733245","doi":"10.1210/me.2004-0496","title":"Epigenetic Regulation by Histone Methylation and Histone Variants","year":2005,"lang":"en","type":"review","venue":"Molecular Endocrinology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":328,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; University of Toronto","keywords":"Biology; Histone methylation; Histone methyltransferase; Epigenomics; Histone code; Epigenetics; Histone H2A; Histone; Cancer epigenetics; Genetics; Epigenetic regulation of neurogenesis; Euchromatin; Histone H1; EZH2; DNA methylation; Chromatin; Heterochromatin; Nucleosome; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003248614,0.0005040202,0.0009496509,0.0007278721,0.0002594106,0.0007118315,0.0006963166,0.0007413462,0.001669594],"category_scores_gemma":[0.000251454,0.000167086,0.0002334317,0.001227243,0.0006991643,0.000755153,0.0004798069,0.0007217117,0.001971063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007299641,"about_ca_system_score_gemma":0.0004541323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009659615,"about_ca_topic_score_gemma":0.0010562,"domain_scores_codex":[0.9998174,0.00003296758,0.00001262682,0.0000510946,0.00006785015,0.00001802222],"domain_scores_gemma":[0.999925,0.00002066143,0.00001523769,0.000006866149,0.00002234062,0.000009863107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009558091,0.00003060867,0.0006544446,0.004569976,0.00008825764,0.0008389423,0.0001852587,0.0006639067,0.05704909,0.02734007,0.01775094,0.890733],"study_design_scores_gemma":[0.000009473692,0.0000565649,0.002160555,0.0004554561,0.00004849061,0.002252213,0.00009427595,0.0001626592,0.01499405,0.008562115,0.9711772,0.0000269982],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001401876,0.9897448,0.002202433,0.0005273204,0.0003460764,0.000006993969,0.00005053993,0.00004506639,0.005674992],"genre_scores_gemma":[0.0123666,0.9789916,0.001586597,0.0003295804,0.0003231453,0.00001345711,0.00007474422,0.000007147282,0.006307169],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001669594,"threshold_uncertainty_score":0.005585313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0209320571319734,"score_gpt":0.339381480085646,"score_spread":0.3184494229536726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}