{"id":"W2032733245","doi":"10.1210/me.2004-0496","title":"Epigenetic Regulation by Histone Methylation and Histone Variants","year":2005,"lang":"en","type":"review","venue":"Molecular Endocrinology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":328,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; University of Toronto","keywords":"Biology; Histone methylation; Histone methyltransferase; Epigenomics; Histone code; Epigenetics; Histone H2A; Histone; Cancer epigenetics; Genetics; Epigenetic regulation of neurogenesis; Euchromatin; Histone H1; EZH2; DNA methylation; Chromatin; Heterochromatin; Nucleosome; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002026525,0.000595286,0.001007906,0.0002442754,0.0001207184,0.00003406652,0.0002802893,0.0007475509,0.00005718853],"category_scores_gemma":[0.0001244474,0.0006247692,0.0002845095,0.0001774644,0.0001824158,0.000005772364,0.0002309305,0.0002932379,0.00004093515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147783,"about_ca_system_score_gemma":0.0001434668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002789022,"about_ca_topic_score_gemma":0.00001308418,"domain_scores_codex":[0.9969313,0.0004826838,0.0007572026,0.001057676,0.0002146226,0.000556568],"domain_scores_gemma":[0.9984571,0.00003846569,0.0004779947,0.0007761275,0.00009744024,0.0001528656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001013324,0.00005566986,0.000002708596,0.0004718135,0.0001722554,0.0000138039,0.000009957873,0.00001627115,0.05878231,0.000270008,0.0004802032,0.9397148],"study_design_scores_gemma":[0.0003710193,0.0002110537,0.00002585595,0.0001543556,0.000472943,0.0000708911,0.000001838038,0.00001633333,0.01415411,0.0001959145,0.9837464,0.0005792738],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006955742,0.9814532,0.01587408,0.00006832924,0.0002896011,0.0006641686,0.00005819335,0.00003272136,0.0008640976],"genre_scores_gemma":[0.001919182,0.9921734,0.0016608,0.00006914841,0.0002465909,0.0001319174,0.002050319,0.0001308955,0.001617782],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9832662,"threshold_uncertainty_score":0.9996204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0209320571319734,"score_gpt":0.339381480085646,"score_spread":0.3184494229536726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}