{"id":"W2032751548","doi":"10.1074/jbc.m201461200","title":"Mannose-binding Lectin (MBL) Mutants Are Susceptible to Matrix Metalloproteinase Proteolysis","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Mannan-binding lectin; Proteolysis; Matrix metalloproteinase; Collagenase; Lectin; Biology; Mutant; Metalloproteinase; Biochemistry; Chemistry; Molecular biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001568845,0.0004206957,0.0002204878,0.0001478041,0.0001074023,0.0002639463,0.0001936265,0.0003482873,0.001017503],"category_scores_gemma":[0.0003073522,0.0001184001,0.0003098203,0.0001395972,0.0002968688,0.0001142656,0.0002728511,0.0003667405,0.0004286971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002986846,"about_ca_system_score_gemma":0.0001412315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009528914,"about_ca_topic_score_gemma":0.0005474135,"domain_scores_codex":[0.9997637,0.00005343668,0.00003105294,0.00003432619,0.00006353568,0.00005397328],"domain_scores_gemma":[0.9997761,0.00003428951,0.00009729079,0.00001886012,0.00001768787,0.00005585315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002173502,0.00003195163,0.0004796396,0.0000159832,0.00001465944,0.0002218758,0.0000209244,0.00007155088,0.9981635,0.00007616668,0.00004015927,0.0006462031],"study_design_scores_gemma":[0.0001238269,0.00173966,0.02346334,0.00001719992,0.00007588815,0.005947853,0.0000997316,0.00163748,0.9608033,0.0001736001,0.005887451,0.00003077108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986398,0.0003210198,0.0006154588,0.00004058889,0.000009854358,0.00001117442,0.0001431181,0.0000256512,0.0001933492],"genre_scores_gemma":[0.99822,0.0001526829,0.0007230302,0.00003839034,0.000005197237,0.00001452452,0.0002936845,0.00001582143,0.0005365494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001017503,"threshold_uncertainty_score":0.003403902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04348175699240618,"score_gpt":0.2779062314825035,"score_spread":0.2344244744900973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}