{"id":"W2032756586","doi":"10.1210/en.2006-1420","title":"Daily Rhythm in Pineal Phosphodiesterase (PDE) Activity Reflects Adrenergic/3′,5′-Cyclic Adenosine 5′-Monophosphate Induction of the PDE4B2 Variant","year":2007,"lang":"en","type":"article","venue":"Endocrinology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Child Health and Human Development; National Institutes of Health","keywords":"Internal medicine; Endocrinology; Pineal gland; Melatonin; Phosphodiesterase; Protein kinase A; Pinealocyte; Stimulation; Biology; Cyclic adenosine monophosphate; Circadian rhythm; Receptor; Adrenergic receptor; Adenylate kinase; Enzyme; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346671,0.0002578422,0.0002395189,0.0004694168,0.0002366689,0.0004320881,0.0001929126,0.0003415859,0.001774944],"category_scores_gemma":[0.0001719643,0.0001878429,0.0002861357,0.0003258167,0.0002540336,0.0002376672,0.000193996,0.0006602741,0.000402313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003274241,"about_ca_system_score_gemma":0.0001666812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001692365,"about_ca_topic_score_gemma":0.002164763,"domain_scores_codex":[0.9998952,0.000009261086,0.000009172538,0.00003786309,0.0000277997,0.00002067247],"domain_scores_gemma":[0.9998626,0.00002399271,0.00003965611,0.00001688974,0.00002146304,0.00003543899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001357759,0.00002282254,0.003982441,0.00004028175,0.0000132582,0.00007086204,0.00003110975,0.00002267699,0.9931207,0.00008485137,0.00008327402,0.002391831],"study_design_scores_gemma":[0.00001544978,0.0002769002,0.4210842,0.00001179212,0.00003420466,0.0007747479,0.0001584585,0.0009090158,0.5720626,0.0002336185,0.004418578,0.00002038845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769506,0.006162928,0.01083001,0.0002490373,0.0001207703,0.00005053617,0.002132508,0.0001574934,0.003346084],"genre_scores_gemma":[0.9884791,0.001576682,0.004403806,0.0001179634,0.00005197326,0.00004597318,0.001741723,0.00004514155,0.00353765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001774944,"threshold_uncertainty_score":0.005937755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02696469618595439,"score_gpt":0.2796546420748899,"score_spread":0.2526899458889356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}