{"id":"W2032756882","doi":"10.1091/mbc.e04-10-0883","title":"Initiation of Embryonic Cardiac Pacemaker Activity by Inositol 1,4,5-Trisphosphate–dependent Calcium Signaling","year":2005,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"Servier; Alberta Heritage Foundation for Medical Research; Institut National de la Santé et de la Recherche Médicale; Centre National de la Recherche Scientifique; Mayo Foundation for Medical Education and Research","keywords":"Biology; Pacemaker potential; Cardiac pacemaker; Endoplasmic reticulum; Inositol; Cell biology; Embryonic stem cell; Calcium; Embryonic heart; Inositol trisphosphate; Inositol trisphosphate receptor; Calcium signaling; Calcium in biology; Neuroscience; Intracellular; Internal medicine; Electrophysiology; Receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001881457,0.0001435943,0.0004301352,0.00004272997,0.00005508144,0.000001559917,0.00007945605,0.0002289551,0.00002688758],"category_scores_gemma":[0.00003857088,0.0001067057,0.0003344706,0.0001249012,0.0001779331,0.00002282626,0.00007876064,0.0002591908,0.000009666085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004796715,"about_ca_system_score_gemma":0.00008451429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003253509,"about_ca_topic_score_gemma":5.66958e-7,"domain_scores_codex":[0.998966,0.0002593539,0.00020719,0.0002241856,0.0001136783,0.0002295919],"domain_scores_gemma":[0.9992392,0.00006280855,0.0002152838,0.0003585247,0.00007858255,0.00004556644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001909305,0.0001036944,0.002124806,0.00003869628,0.0001298624,0.000007196916,0.00004159162,0.0001571572,0.9961487,0.00007261959,0.0004465859,0.0005381356],"study_design_scores_gemma":[0.0006583641,0.0001763753,0.002263825,0.00002056687,0.0001831213,0.00001593671,0.00001031879,0.00004416848,0.9959996,0.00008229478,0.0004522121,0.00009326754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936712,0.00332582,0.0008729622,0.00107489,0.0001951476,0.0003161718,0.0000300762,0.00001362718,0.0005000369],"genre_scores_gemma":[0.9991253,0.00007405868,0.0001532185,0.0002669684,0.00007114073,0.00001147835,0.00002653358,0.00001440224,0.0002568693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005454062,"threshold_uncertainty_score":0.4351331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006515130146370104,"score_gpt":0.2541529342006945,"score_spread":0.2476378040543244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}