{"id":"W2032756882","doi":"10.1091/mbc.e04-10-0883","title":"Initiation of Embryonic Cardiac Pacemaker Activity by Inositol 1,4,5-Trisphosphate–dependent Calcium Signaling","year":2005,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"Servier; Alberta Heritage Foundation for Medical Research; Institut National de la Santé et de la Recherche Médicale; Centre National de la Recherche Scientifique; Mayo Foundation for Medical Education and Research","keywords":"Biology; Pacemaker potential; Cardiac pacemaker; Endoplasmic reticulum; Inositol; Cell biology; Embryonic stem cell; Calcium; Embryonic heart; Inositol trisphosphate; Inositol trisphosphate receptor; Calcium signaling; Calcium in biology; Neuroscience; Intracellular; Internal medicine; Electrophysiology; Receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001329831,0.000171384,0.0001131095,0.00009553901,0.00008701191,0.0002850961,0.0001533802,0.0001908634,0.0006004591],"category_scores_gemma":[0.0001962348,0.0001258743,0.000118618,0.00005173824,0.0002044605,0.00015807,0.000248841,0.0004258464,0.0003075043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001720999,"about_ca_system_score_gemma":0.0001489262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002198622,"about_ca_topic_score_gemma":0.0004014581,"domain_scores_codex":[0.9999297,0.000008925484,0.000008004979,0.00001340669,0.00002500303,0.00001498022],"domain_scores_gemma":[0.9998837,0.00003435081,0.00003224561,0.00001692599,0.00001037661,0.00002237195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003501364,0.000005110763,0.0003123804,0.00001492056,0.000001179104,0.00008238102,0.00001611453,0.00006724615,0.9968525,0.0006390069,0.00002542367,0.001948704],"study_design_scores_gemma":[0.00001657479,0.00009036197,0.006741849,0.00001067346,0.000005801453,0.0003769827,0.00002311276,0.001185136,0.9870155,0.0002678333,0.004261618,0.00000468741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794183,0.001484002,0.01467755,0.0001028471,0.00004129185,0.00003114067,0.0002758925,0.000166821,0.003802072],"genre_scores_gemma":[0.9900044,0.0009170212,0.006476592,0.00005763167,0.000007497896,0.00002405061,0.0002445587,0.0000242,0.00224406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006004591,"threshold_uncertainty_score":0.002008736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006515130146370104,"score_gpt":0.2541529342006945,"score_spread":0.2476378040543244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}