{"id":"W2032804887","doi":"10.1038/eye.2012.174","title":"Pilot study to evaLuate the role of high-dose rAnibizumab 2.0 mg in the management of neovascular age-related macular degeneration in patients with perSistent/recurrenT macular fluid <30 days following treatment with intravitreal anti-VEGF therapy (the LAST Study)","year":2012,"lang":"en","type":"article","venue":"Eye","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Columbia College","funders":"","keywords":"Ranibizumab; Medicine; Macular degeneration; Ophthalmology; Visual acuity; Pro re nata; Choroidal neovascularization; Randomized controlled trial; Bevacizumab; Prospective cohort study; Regimen; Ophthalmic pathology; Neuro-ophthalmology; Surgery; Glaucoma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005813507,0.0003350189,0.0004921044,0.0001204786,0.0001272559,0.0000262044,0.0002086147,0.00001884418,0.00002497241],"category_scores_gemma":[0.000004173443,0.0001415586,0.0001798062,0.0005247878,0.00005176816,0.00007607967,0.00004991632,0.0001034838,0.000006762611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001906495,"about_ca_system_score_gemma":0.00003388554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007333047,"about_ca_topic_score_gemma":0.0001529994,"domain_scores_codex":[0.9973158,0.0005409084,0.0004429163,0.0003492626,0.001004306,0.0003467706],"domain_scores_gemma":[0.9989736,0.0000292533,0.0001177159,0.0007151271,0.00007814022,0.00008616539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003918579,0.03007101,0.9370338,0.00002542502,0.004651839,0.0001745311,0.01341322,0.0007393858,0.0003563677,0.00003754077,0.00000297627,0.009575313],"study_design_scores_gemma":[0.02504111,0.02157141,0.9414685,0.0001675971,0.002571327,0.000001709728,0.008662816,0.00009245738,0.0002499184,0.000006564642,0.00002279006,0.0001437562],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908893,0.001749787,0.000004207644,0.00006818886,0.00006596012,0.007123528,0.000008206632,0.00001037786,0.00008048554],"genre_scores_gemma":[0.9992355,0.00008285393,0.00005426093,0.00002501216,0.00002110415,0.0004472118,0.00008323273,0.00003445179,0.00001636471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02112254,"threshold_uncertainty_score":0.5772594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156184576577394,"score_gpt":0.2665659549063277,"score_spread":0.2509474972485883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}