{"id":"W2032826269","doi":"10.1021/np060285e","title":"Inhibition of the G<sub>2</sub> DNA Damage Checkpoint by Oliveroline Isolated from <i>Duguetia odorata</i>","year":2007,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"G2-M DNA damage checkpoint; Fractionation; Bioassay; Alkaloid; DNA damage; Botany; Biology; Chemistry; DNA; Traditional medicine; Cell cycle checkpoint; Biochemistry; Chromatography; Cell cycle; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002879782,0.0001417819,0.0002086363,0.0000214742,0.00006561189,0.00001133479,0.0001732765,0.0001085278,0.000001914557],"category_scores_gemma":[0.0002313692,0.00008809887,0.0001362796,0.000157412,0.0001362521,0.00001482386,0.0001386504,0.0002941218,7.642209e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002602359,"about_ca_system_score_gemma":0.0000393029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001010989,"about_ca_topic_score_gemma":0.00001936704,"domain_scores_codex":[0.998977,0.00003968196,0.0003937107,0.0001719747,0.0002249125,0.0001926911],"domain_scores_gemma":[0.9989133,0.00001873153,0.0004795642,0.000185687,0.0003560385,0.00004667139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004207463,0.00008922482,0.0001130216,0.00001513712,0.00009373328,0.00000383879,0.00003610616,0.000001196749,0.9858266,0.000001169034,0.01251055,0.0008886466],"study_design_scores_gemma":[0.0005164334,0.0002033548,0.002243414,0.00005032997,0.00003820921,0.00002218144,0.00006183491,0.000003377307,0.9936008,0.00007129422,0.003077548,0.0001112555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934479,0.00479974,0.00004580165,0.001058398,0.0004222961,0.0001035183,0.00005955754,0.000002957688,0.00005980597],"genre_scores_gemma":[0.9983467,0.0004015669,0.00009761511,0.0002782748,0.0007853875,3.661509e-7,0.00004606888,0.00001061227,0.00003335262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009433004,"threshold_uncertainty_score":0.3592567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005023817146781972,"score_gpt":0.2039877586283726,"score_spread":0.1989639414815906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}