{"id":"W2032843495","doi":"10.1186/bcr1902","title":"Accurate prediction of BRCA1 and BRCA2 heterozygous genotypes using expression profiling of lymphocytes after irradiation-induced DNA damage","year":2008,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; Biotechnology and Biological Sciences Research Council; Medical Research Council; Allergan; Keele University; Ministerio de Economía y Competitividad; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Tenovus; Breast Cancer Campaign; Breast Cancer Research Trust; World Cancer Research Fund; University of Sheffield; National Health and Medical Research Council; Cancer Research UK; European Commission; Royal Marsden NHS Foundation Trust; John and Lucille Van Geest Foundation; University of Bristol; University of Glasgow; Ludwig Institute for Cancer Research; AstraZeneca","keywords":"Surgical oncology; DNA damage; Genotype; Gene expression profiling; DNA profiling; DNA repair; Biology; Genetics; Cancer research; DNA; Medicine; Gene expression; Oncology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128881,0.0001367404,0.0003174755,0.0002847027,0.00009176802,0.0003564634,0.0001023696,0.0003045898,0.0003308068],"category_scores_gemma":[0.0009397244,0.00009901432,0.0001268902,0.0002171563,0.00009481982,0.0001586739,0.00008134996,0.0002413559,0.0001717812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001159202,"about_ca_system_score_gemma":0.0000752996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003769272,"about_ca_topic_score_gemma":0.000472062,"domain_scores_codex":[0.9998093,0.00004332558,0.00001373858,0.00005036339,0.00005386205,0.00002946666],"domain_scores_gemma":[0.9997003,0.0001716993,0.00004479881,0.0000241059,0.00004434949,0.000014827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006006967,0.00008436521,0.05263642,0.0000284993,0.00002067393,0.00009836652,0.00008639973,0.001651943,0.9197145,0.00005187063,0.0000924768,0.02493381],"study_design_scores_gemma":[0.00002643487,0.0009289556,0.4300421,0.00001772,0.00009720318,0.0008653766,0.0003105575,0.06110257,0.5047084,0.0004593675,0.001407341,0.00003384305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943883,0.0001958672,0.004976497,0.00003125909,0.000005354924,0.000006597016,0.0001729594,0.00002629268,0.000196926],"genre_scores_gemma":[0.9943951,0.0001470929,0.004676316,0.00001645571,0.000005692655,0.00001511696,0.0003831254,0.000005049449,0.0003560048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003769272,"threshold_uncertainty_score":0.001654744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04381490101314298,"score_gpt":0.3648209288304947,"score_spread":0.3210060278173517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}