{"id":"W2032843495","doi":"10.1186/bcr1902","title":"Accurate prediction of BRCA1 and BRCA2 heterozygous genotypes using expression profiling of lymphocytes after irradiation-induced DNA damage","year":2008,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; Biotechnology and Biological Sciences Research Council; Medical Research Council; Allergan; Keele University; Ministerio de Economía y Competitividad; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Tenovus; Breast Cancer Campaign; Breast Cancer Research Trust; World Cancer Research Fund; University of Sheffield; National Health and Medical Research Council; Cancer Research UK; European Commission; Royal Marsden NHS Foundation Trust; John and Lucille Van Geest Foundation; University of Bristol; University of Glasgow; Ludwig Institute for Cancer Research; AstraZeneca","keywords":"Surgical oncology; DNA damage; Genotype; Gene expression profiling; DNA profiling; DNA repair; Biology; Genetics; Cancer research; DNA; Medicine; Gene expression; Oncology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001765026,0.0000871524,0.0001154464,0.0000902306,0.00007137616,0.000007877298,0.0000860385,0.00008985801,0.00001711443],"category_scores_gemma":[0.00002655656,0.00008275489,0.00003168506,0.0001207172,0.00008842166,0.00000852118,0.0001008013,0.0000721807,3.677861e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003307101,"about_ca_system_score_gemma":0.0001606772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00024285,"about_ca_topic_score_gemma":0.00001191361,"domain_scores_codex":[0.9991183,0.00005580793,0.0001799721,0.0002271485,0.0002195917,0.0001992092],"domain_scores_gemma":[0.9994767,0.00001352616,0.00004728118,0.0001999979,0.0002020379,0.00006050926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001977184,0.00002120051,0.01247957,0.00009727616,0.00002163466,0.00000232014,0.0001633822,0.001157247,0.9850273,9.93306e-7,0.00001432621,0.0008170366],"study_design_scores_gemma":[0.0003603607,0.00006595427,0.1685036,0.00005571319,0.000005542386,0.00003851834,0.00004984031,0.001998934,0.8288299,0.00000283503,0.00002795282,0.00006077176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973279,0.001687531,0.0005997837,0.00001368636,0.00005283552,0.0001746925,0.000107128,0.000005117016,0.00003137813],"genre_scores_gemma":[0.9988112,0.0004793069,0.0004728824,0.000004315548,0.00014739,0.00003232354,0.00001527893,0.00001756796,0.00001974528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1561974,"threshold_uncertainty_score":0.3374646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04381490101314298,"score_gpt":0.3648209288304947,"score_spread":0.3210060278173517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}