{"id":"W2032846642","doi":"10.1016/j.cellsig.2008.08.007","title":"PGE2 induces COX-2 expression in podocytes via the EP4 receptor through a PKA-independent mechanism","year":2008,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Forskolin; Cell biology; Protein kinase A; MAPK/ERK pathway; Cyclic AMP Response Element-Binding Protein; Prostaglandin E2 receptor; AMPK; Chemistry; Gene knockdown; p38 mitogen-activated protein kinases; Downregulation and upregulation; Signal transduction; Activator (genetics); IBMX; Receptor; Prostaglandin E2; Internal medicine; Phosphorylation; Endocrinology; Biology; CREB; Transcription factor; Agonist; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690764,0.0003771378,0.000327903,0.0003643609,0.0002712182,0.0003639238,0.0001972258,0.0003178447,0.002836507],"category_scores_gemma":[0.0002578129,0.0001853473,0.0005536708,0.0001397353,0.000380367,0.0003871117,0.0003883457,0.0008429282,0.0005863098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004324082,"about_ca_system_score_gemma":0.0003452744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007247829,"about_ca_topic_score_gemma":0.0008241169,"domain_scores_codex":[0.9998022,0.00005543189,0.00001324581,0.00002164481,0.00004737074,0.0000602547],"domain_scores_gemma":[0.9998266,0.00004304081,0.00002882808,0.00002791759,0.00003110823,0.00004254091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001195513,0.00007586108,0.0004515809,0.0001303687,0.00001563626,0.0003115704,0.00003145564,0.00006302783,0.994869,0.0004008813,0.0001271278,0.002327994],"study_design_scores_gemma":[0.0001522171,0.0005630065,0.02072253,0.00001459588,0.00003664491,0.0004880663,0.0001109402,0.0008050142,0.9739555,0.0003800094,0.002759924,0.00001159642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789454,0.00468409,0.007298611,0.0006802994,0.0002293701,0.0001197863,0.0005616029,0.00009571731,0.007385225],"genre_scores_gemma":[0.9845659,0.001702252,0.003023716,0.0001802863,0.0001047678,0.0000953386,0.000466452,0.00001712868,0.009844043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002836507,"threshold_uncertainty_score":0.009489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02835193104514206,"score_gpt":0.2498774974414288,"score_spread":0.2215255663962868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}