{"id":"W2032846642","doi":"10.1016/j.cellsig.2008.08.007","title":"PGE2 induces COX-2 expression in podocytes via the EP4 receptor through a PKA-independent mechanism","year":2008,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Forskolin; Cell biology; Protein kinase A; MAPK/ERK pathway; Cyclic AMP Response Element-Binding Protein; Prostaglandin E2 receptor; AMPK; Chemistry; Gene knockdown; p38 mitogen-activated protein kinases; Downregulation and upregulation; Signal transduction; Activator (genetics); IBMX; Receptor; Prostaglandin E2; Internal medicine; Phosphorylation; Endocrinology; Biology; CREB; Transcription factor; Agonist; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003381038,0.0002391375,0.0003481544,0.00009112438,0.000263579,0.0000286105,0.0001895184,0.0001483715,0.000445635],"category_scores_gemma":[0.0000791553,0.000157364,0.0001844468,0.0002552191,0.00009130793,0.000152097,0.00008513344,0.0003989664,0.0001400224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006555142,"about_ca_system_score_gemma":0.00009654542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008579426,"about_ca_topic_score_gemma":0.000003371767,"domain_scores_codex":[0.998157,0.0001461815,0.0003914668,0.0003799629,0.0005460734,0.0003793376],"domain_scores_gemma":[0.9992135,0.0001339431,0.000128531,0.0003121035,0.00007698882,0.0001349818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000160973,0.0001954073,0.0007156268,0.00009430214,0.00003310273,0.0004438992,0.002161424,0.00008155659,0.9947376,0.0003321395,0.0002237336,0.0008202053],"study_design_scores_gemma":[0.001063008,0.0001798176,0.0008961827,0.0006329179,0.00005965103,0.00006304732,0.001038052,0.0008673431,0.9906973,0.002372981,0.001869308,0.0002603973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731457,0.01003206,0.01490203,0.0004005044,0.0002440667,0.0004726375,0.000004712865,0.00006687191,0.0007314496],"genre_scores_gemma":[0.9959695,0.001498071,0.001245643,0.0003700456,0.0003170126,0.00004493753,0.0000369032,0.00003746213,0.0004804755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02282378,"threshold_uncertainty_score":0.6417118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02835193104514206,"score_gpt":0.2498774974414288,"score_spread":0.2215255663962868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}