{"id":"W2032881765","doi":"10.1021/bi0600953","title":"Equilibrium Thermodynamic Analysis of Amyotrophic Lateral Sclerosis-Associated Mutant Apo Cu,Zn Superoxide Dismutases<sup>,</sup>","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Waterloo","funders":"","keywords":"Dimer; Chemistry; Monomer; Differential scanning calorimetry; Crystallography; Guanidinium chloride; Mutant; Protein folding; Protein aggregation; Calorimetry; Biophysics; Biochemistry; Thermodynamics; Polymer; Biology; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003256619,0.0004615733,0.001056824,0.0003096276,0.00008733076,0.00005896858,0.0004439091,0.0004577227,0.0008712092],"category_scores_gemma":[0.0001723215,0.0003946752,0.0007000733,0.001725739,0.0004118645,0.0001122968,0.0002395496,0.0004761182,0.00003124836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005380561,"about_ca_system_score_gemma":0.0002221125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001582628,"about_ca_topic_score_gemma":0.00002598953,"domain_scores_codex":[0.9962479,0.0001156737,0.0008868061,0.0007793317,0.001052859,0.0009173568],"domain_scores_gemma":[0.9979883,0.0001104272,0.0002458458,0.001024529,0.0003090972,0.0003218083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002432098,0.0005741696,0.05995649,0.0001258121,0.001262323,0.00006300586,0.00006478738,0.0004268686,0.9367723,0.00001068936,0.0003161679,0.0001841927],"study_design_scores_gemma":[0.002671479,0.0002193516,0.6089525,0.0003729065,0.002062185,0.00002051457,0.00007548377,0.08049366,0.3044298,0.00008676828,0.00002372365,0.000591615],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972262,0.0003430324,0.00001644389,0.0005975048,0.0000319745,0.000328365,0.0004378339,0.0001591039,0.0008595029],"genre_scores_gemma":[0.9963581,0.00005489933,0.0001050737,0.0001050229,0.0001996695,0.00003884422,0.001669116,0.00007807234,0.001391208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6323425,"threshold_uncertainty_score":0.9998505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01683622772212346,"score_gpt":0.2553035189930545,"score_spread":0.2384672912709311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}