{"id":"W2032894916","doi":"10.1158/1538-7445.am2011-2829","title":"Abstract 2829: Preclinical characterization of TKM-080301, a lipid nanoparticle formulation of a small interfering RNA directed against polo-like kinase 1","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Gene silencing; RNA interference; Small interfering RNA; PLK1; Polo-like kinase; Biology; Cytokinesis; Cell biology; Cancer research; Dicer; Kinase; Cell cycle; Cell; RNA; Cell division; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003588613,0.0004577615,0.0003237672,0.0002304617,0.0001332869,0.0002794829,0.0003193016,0.0003458599,0.002271819],"category_scores_gemma":[0.0002985624,0.0001736635,0.0002386093,0.0001176194,0.0002095104,0.0002511897,0.000113751,0.0007624127,0.001182877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003538659,"about_ca_system_score_gemma":0.0005983933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008164548,"about_ca_topic_score_gemma":0.0009641502,"domain_scores_codex":[0.9998916,0.00002246618,0.000006498861,0.00001923103,0.00003819086,0.000021941],"domain_scores_gemma":[0.9998486,0.00003025069,0.00003795308,0.00001139641,0.00003372502,0.00003812816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001053421,0.001448416,0.0003301956,0.00008546373,0.00001298469,0.00008423099,0.0000327981,0.0008801928,0.9867203,0.0001099539,0.0004401632,0.008801962],"study_design_scores_gemma":[0.0003631558,0.02194513,0.002655425,0.00001243647,0.00004886457,0.0002592602,0.0000286705,0.004147583,0.9647813,0.00007072418,0.005676329,0.00001109559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853039,0.001124604,0.007091434,0.0001868769,0.00007213285,0.0008063682,0.0009046058,0.0001340556,0.004375988],"genre_scores_gemma":[0.9856365,0.001005653,0.004439382,0.0001302937,0.00001984828,0.0005484158,0.001475527,0.00006940388,0.006674968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002271819,"threshold_uncertainty_score":0.007600009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129581174884755,"score_gpt":0.3769970726700304,"score_spread":0.2474158977852754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}