{"id":"W2032901020","doi":"10.1158/1538-7445.am2014-ct201","title":"Abstract CT201: Phase I study of 5-azacytidine and oxaliplatin in patients with advanced cancers relapsed or refractory to platinum compounds","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Oxaliplatin; Medicine; Carboplatin; Cisplatin; Internal medicine; Refractory (planetary science); DNA methylation; Gastroenterology; Cancer; Oncology; Chemotherapy; Colorectal cancer; Chemistry; Gene expression; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001049993,0.001541761,0.002544307,0.0004693692,0.0004708641,0.0006873606,0.0009356893,0.001040654,0.004882217],"category_scores_gemma":[0.000762728,0.0005639884,0.001000933,0.0006596882,0.0009845744,0.0007336242,0.0004346937,0.002542521,0.0009641741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001065845,"about_ca_system_score_gemma":0.001863142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001780724,"about_ca_topic_score_gemma":0.003359532,"domain_scores_codex":[0.9996046,0.0001906392,0.00002307939,0.00006860412,0.00003724581,0.0000757453],"domain_scores_gemma":[0.9993657,0.00008562598,0.00009480247,0.00006357615,0.00003369266,0.0003564818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7132658,0.08249635,0.01209671,0.0008029015,0.001002683,0.0005277549,0.0003149294,0.003146991,0.1098521,0.0002781653,0.003175098,0.07304066],"study_design_scores_gemma":[0.3693374,0.5987894,0.01896408,0.00003476132,0.0004428593,0.0005541472,0.00005529736,0.001188651,0.008344902,0.0001102022,0.002151517,0.00002673993],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945056,0.001017782,0.0003347661,0.000189588,0.0000524167,0.00161732,0.0008185514,0.00007833473,0.001385706],"genre_scores_gemma":[0.9889848,0.0009004855,0.001468948,0.0004107198,0.0001507714,0.002046366,0.003551771,0.00002795722,0.002458118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004882217,"threshold_uncertainty_score":0.01633263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03666465285970764,"score_gpt":0.3886147165408582,"score_spread":0.3519500636811506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}