{"id":"W2032907584","doi":"10.1038/aps.2011.64","title":"Calcium binding protein-mediated regulation of voltage-gated calcium channels linked to human diseases","year":2011,"lang":"en","type":"review","venue":"Acta Pharmacologica Sinica","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Calcium; Voltage-dependent calcium channel; N-type calcium channel; R-type calcium channel; Calcium channel; Ion channel; Calcium signaling; Calcium-binding protein; Cell biology; Chemistry; T-type calcium channel; Biophysics; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004584337,0.001012863,0.001499484,0.001399581,0.0002612346,0.0007494675,0.001039522,0.0009926391,0.002146807],"category_scores_gemma":[0.0004168277,0.0002876247,0.0004333098,0.001753573,0.0006202662,0.0007857599,0.0005839051,0.001781578,0.001761715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006008862,"about_ca_system_score_gemma":0.0008984233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008292857,"about_ca_topic_score_gemma":0.001353054,"domain_scores_codex":[0.9998651,0.00001942212,0.0000229527,0.00002860582,0.00004605644,0.00001792861],"domain_scores_gemma":[0.9998379,0.0000606608,0.0000327713,0.000008026657,0.00004257013,0.00001809708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002361142,0.0001670437,0.0003497158,0.01308429,0.0001399307,0.0007665174,0.00005582394,0.0004640432,0.009978121,0.005119142,0.02897156,0.9406677],"study_design_scores_gemma":[0.00008985025,0.0001294705,0.002178522,0.001920554,0.0002901821,0.003722577,0.00005504097,0.0002226245,0.002965316,0.002799959,0.9855933,0.00003263833],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002161063,0.998282,0.0002881602,0.0001890663,0.0002047985,0.000005950088,0.0000184116,0.000009781067,0.0007858255],"genre_scores_gemma":[0.001164371,0.9975707,0.0003269096,0.0001537789,0.0002142679,0.000008318817,0.00003716701,0.000001558042,0.0005229543],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002146807,"threshold_uncertainty_score":0.007181823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1044840610357798,"score_gpt":0.3714162891539022,"score_spread":0.2669322281181224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}