{"id":"W2032915605","doi":"10.1039/c1md00195g","title":"Structure–activity relationships of methyl-lysine reader antagonists","year":2011,"lang":"en","type":"article","venue":"MedChemComm","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium; Toronto Public Health","funders":"","keywords":"Lysine; Computational biology; Stereochemistry; Chemistry; Biology; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003738683,0.0005212409,0.0004564675,0.0003467256,0.000212619,0.0004370562,0.0004332356,0.0003685159,0.002055297],"category_scores_gemma":[0.0003534901,0.0002696961,0.0003766345,0.0002482561,0.0001969334,0.0002203236,0.0001346734,0.0009409972,0.0007448402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000552367,"about_ca_system_score_gemma":0.0002553407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005720843,"about_ca_topic_score_gemma":0.002148008,"domain_scores_codex":[0.9997939,0.00005621915,0.00001714636,0.00002764111,0.00005325687,0.00005182762],"domain_scores_gemma":[0.9998298,0.00005435543,0.0000363766,0.00001397513,0.00003008547,0.0000354761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006205624,0.0003777294,0.0003372188,0.0001006607,0.0000584715,0.00009567169,0.00003426368,0.001363923,0.9891173,0.0003762848,0.0003226583,0.00719526],"study_design_scores_gemma":[0.0003559967,0.00594785,0.002885333,0.00001393932,0.0001135145,0.0009319633,0.00002924937,0.003389609,0.9774715,0.0001989365,0.008635505,0.00002657665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965802,0.01538752,0.008385831,0.0004133954,0.00008869849,0.0003466345,0.001086379,0.000194866,0.008294791],"genre_scores_gemma":[0.9799732,0.007305399,0.004875055,0.0001661345,0.00003066478,0.0001422443,0.002259517,0.00003147741,0.00521628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002055297,"threshold_uncertainty_score":0.006875634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04852003140383111,"score_gpt":0.255137882323673,"score_spread":0.2066178509198419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}