{"id":"W2032933113","doi":"10.3389/fbioe.2015.00014","title":"Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines","year":2015,"lang":"en","type":"article","venue":"Frontiers in Bioengineering and Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Cure Brain Cancer Foundation; Alberta Innovates; Alberta Innovates - Health Solutions; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Cell cycle; Small interfering RNA; Biology; Cancer research; Cell biology; RNA interference; Cell cycle checkpoint; CDC20; Cancer cell; Gene silencing; Cell; Cancer; Biochemistry; Transfection; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008694934,0.00018866,0.0001987831,0.000196584,0.00002359934,0.00001510288,0.0001540038,0.0003544188,9.683982e-7],"category_scores_gemma":[0.000008298809,0.0001702064,0.000018326,0.0002285512,0.0001111762,0.000009726411,0.00007758649,0.0001858019,4.695863e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004536225,"about_ca_system_score_gemma":0.00005044394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004150292,"about_ca_topic_score_gemma":0.00003874396,"domain_scores_codex":[0.9990678,0.00001498953,0.0001760913,0.0003471765,0.0000650072,0.0003289497],"domain_scores_gemma":[0.9996992,0.000001695491,0.00004938801,0.0001567451,0.00003022089,0.00006269815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008287706,0.00003945555,0.0148715,0.00002693931,0.00001688797,0.000009965851,0.00005594861,0.008664598,0.9742326,8.031561e-7,0.0009349372,0.001063497],"study_design_scores_gemma":[0.0008463025,0.0001468394,0.0002162175,0.00006729765,0.000009017085,0.00002334636,0.0004430965,0.01164924,0.9846446,0.000004430887,0.001635642,0.00031397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833475,0.004699182,0.0111461,0.0002866753,0.0002926007,0.0001515968,0.00003658177,0.00003158639,0.00000813214],"genre_scores_gemma":[0.9911649,0.001403777,0.007227436,0.00003668677,0.00007264398,0.00002085072,0.00002105575,0.00002197397,0.00003073931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01465528,"threshold_uncertainty_score":0.6940815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005542985038236204,"score_gpt":0.1975264402325198,"score_spread":0.1919834551942836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}