{"id":"W2032952923","doi":"10.1016/j.biotechadv.2008.10.003","title":"From the first to the third generation adenoviral vector: What parameters are governing the production yield?","year":2008,"lang":"en","type":"review","venue":"Biotechnology Advances","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Biotechnology Research Institute; Polytechnique Montréal; National Research Council Canada","funders":"","keywords":"Viral vector; Vector (molecular biology); Genetic enhancement; Commercialization; Virology; Productivity; Gene delivery; Biology; First generation; Computational biology; Biotechnology; Medicine; Gene; Genetics; Recombinant DNA; Business","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001597163,0.001103132,0.002284349,0.001178525,0.0002845972,0.00205933,0.00190424,0.001670806,0.002209795],"category_scores_gemma":[0.001045773,0.0004282031,0.0005101191,0.001857169,0.001147502,0.003260266,0.0006433835,0.002736439,0.002567419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001218411,"about_ca_system_score_gemma":0.001027396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009334317,"about_ca_topic_score_gemma":0.00115155,"domain_scores_codex":[0.9997035,0.00004513055,0.00004191837,0.00005970987,0.000117009,0.00003265487],"domain_scores_gemma":[0.9995239,0.0002587417,0.00006863425,0.00002021925,0.00009966567,0.00002891444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001628457,0.0000800916,0.0002621186,0.01124831,0.00006082017,0.0003044741,0.00007132508,0.0008127217,0.02181895,0.01247851,0.01653575,0.9361641],"study_design_scores_gemma":[0.00004239143,0.000213755,0.0006840057,0.002127964,0.0001408739,0.001663741,0.0001085022,0.0004228381,0.01843381,0.009171284,0.9669335,0.00005726214],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004600924,0.9958131,0.001497743,0.0006179152,0.0002520021,0.000007445179,0.00002753959,0.00002161401,0.001302556],"genre_scores_gemma":[0.001998272,0.9951899,0.001466145,0.0003085688,0.0001423798,0.00001227939,0.00005054643,0.000007853637,0.0008239883],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002284349,"threshold_uncertainty_score":0.008840203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04715211055306427,"score_gpt":0.3157124335371945,"score_spread":0.2685603229841302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}