{"id":"W2032980263","doi":"10.1016/j.chembiol.2011.12.001","title":"Better Chemistry through Regulation","year":2011,"lang":"en","type":"letter","venue":"Chemistry & Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Chemical biology; Synthetic biology; Metabolite; Biology; Computational biology; Secondary metabolite; Chemistry; Biochemistry; Biochemical engineering; Gene; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007891743,0.0004618177,0.0006820299,0.00001580811,0.00006250865,0.00001299876,0.0002703254,0.002899773,0.01118492],"category_scores_gemma":[0.0001302867,0.0003555287,0.0002627336,0.00009741481,0.0003292307,0.00003255362,0.0001090824,0.001857737,0.000181399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001003788,"about_ca_system_score_gemma":0.0001021421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002733187,"about_ca_topic_score_gemma":1.10716e-7,"domain_scores_codex":[0.9980968,0.00002400889,0.0004040063,0.000866689,0.0001112264,0.0004972225],"domain_scores_gemma":[0.9986396,0.00004082769,0.0002662139,0.0008423723,0.0001525828,0.00005843763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002457401,0.00001451112,0.00002715734,0.000542302,0.00007505253,0.00004719183,0.000009857684,2.234488e-9,0.5032729,3.739636e-7,0.4952745,0.0007115599],"study_design_scores_gemma":[0.0001558564,0.00001238711,0.00001871668,0.00008096828,0.0001162374,0.0001835345,0.000001448565,2.527083e-7,0.4765291,0.0002040234,0.5224873,0.000210152],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04860595,0.00192167,0.00001385946,0.8852088,0.0005925857,0.0004149588,0.0001979161,0.0002526311,0.06279165],"genre_scores_gemma":[0.04371357,0.0003289611,0.001421403,0.7988789,0.03629324,0.00001088932,0.01097249,0.0001584963,0.108222],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.08632984,"threshold_uncertainty_score":0.9998897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192508208713511,"score_gpt":0.244799518864075,"score_spread":0.2228744367769399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}