{"id":"W2032980263","doi":"10.1016/j.chembiol.2011.12.001","title":"Better Chemistry through Regulation","year":2011,"lang":"en","type":"letter","venue":"Chemistry & Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Chemical biology; Synthetic biology; Metabolite; Biology; Computational biology; Secondary metabolite; Chemistry; Biochemistry; Biochemical engineering; Gene; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005764762,0.0009021544,0.001175211,0.0004245846,0.002948279,0.00479168,0.001456129,0.02669836,0.00747488],"category_scores_gemma":[0.01443275,0.0005425913,0.0009698928,0.000290372,0.01182533,0.006715879,0.004727831,0.04929378,0.004107004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004562922,"about_ca_system_score_gemma":0.002822762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001234319,"about_ca_topic_score_gemma":0.002335042,"domain_scores_codex":[0.9959499,0.001032468,0.0002762069,0.0005918952,0.001569703,0.0005799172],"domain_scores_gemma":[0.9936141,0.003220057,0.0004464107,0.000730245,0.0007432764,0.001245894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001255266,0.00009919022,0.0002691468,0.0001591837,0.0000417511,0.0009346,0.0002847494,0.0001300341,0.001617878,0.09068026,0.8750528,0.03060482],"study_design_scores_gemma":[0.000096426,0.00006791712,0.000200445,0.00008192165,0.0000181882,0.0006100329,0.0001405773,0.0002149759,0.0008840826,0.08251461,0.9151364,0.00003434262],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004069178,0.007898191,0.0006452602,0.9557921,0.0288336,0.000007944226,0.00001345992,0.00005048095,0.006352025],"genre_scores_gemma":[0.01400979,0.003919321,0.0004695651,0.9372354,0.03188316,0.00004103186,0.00001436107,0.00002511645,0.01240226],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02669836,"threshold_uncertainty_score":0.03310651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192508208713511,"score_gpt":0.244799518864075,"score_spread":0.2228744367769399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}