{"id":"W2033074374","doi":"10.1016/j.bbamem.2012.10.008","title":"Mutual inhibition through hybrid oligomer formation of daptomycin and the semisynthetic lipopeptide antibiotic CB-182,462","year":2012,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Yeshiva University; California HIV/AIDS Research Program","keywords":"Daptomycin; Oligomer; Lipopeptide; Phosphatidylglycerol; Chemistry; Pyrophosphate; Membrane; Antibacterial activity; Bacillus subtilis; Biophysics; Biochemistry; Stereochemistry; Bacteria; Biology; Phospholipid; Organic chemistry; Staphylococcus aureus; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378712,0.0002350386,0.0002073312,0.0001008186,0.0001481782,0.0003880768,0.0001325937,0.0002472725,0.0007719664],"category_scores_gemma":[0.0001448186,0.0001436466,0.0001697827,0.00008350616,0.0001587665,0.0002055197,0.0003463816,0.0004692162,0.0002461397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003314761,"about_ca_system_score_gemma":0.0001806181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001734026,"about_ca_topic_score_gemma":0.0003266036,"domain_scores_codex":[0.9998734,0.00002163805,0.000009584664,0.00002912934,0.00003152978,0.00003466553],"domain_scores_gemma":[0.9998944,0.00003010674,0.00002829653,0.00001105705,0.000007991257,0.00002823754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008343621,0.00001428381,0.00009020488,0.00001179256,0.000004350766,0.00002495864,0.00001001136,0.00009395795,0.9991449,0.0001408869,0.00001571513,0.0003653789],"study_design_scores_gemma":[0.00001713997,0.0001544267,0.000758734,0.000003260053,0.00001026616,0.00007822733,0.00001869379,0.001980892,0.9960227,0.00004303187,0.0009091434,0.00000360685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976031,0.0003142112,0.0008519285,0.00002866364,0.00001402152,0.000008348279,0.00002603306,0.00002478647,0.001128786],"genre_scores_gemma":[0.9986099,0.0001004802,0.000561266,0.00001524575,0.000002744625,0.000009449305,0.00004894814,0.000006778666,0.000645219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007719664,"threshold_uncertainty_score":0.00258249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234838650375572,"score_gpt":0.2288363458362106,"score_spread":0.2164879593324549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}