{"id":"W2033078160","doi":"10.1021/jm200045v","title":"Small-Molecule Ligands of Methyl-Lysine Binding Proteins","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Chemistry; Lysine; Histone; Small molecule; Peptide; Histone H3; Biochemistry; Epigenetics; Chromatin; Binding site; Stereochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000600614,0.0001281945,0.0002474635,0.00004825541,0.00002852073,0.000004568729,0.0002298667,0.0001582898,0.00007724333],"category_scores_gemma":[0.0002874332,0.00010592,0.0001486046,0.000104817,0.00008614533,0.000003488051,0.00005023213,0.000181701,8.589472e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000140336,"about_ca_system_score_gemma":0.0001432397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008007986,"about_ca_topic_score_gemma":0.000001211733,"domain_scores_codex":[0.9989195,0.0000220754,0.0005100999,0.0001342846,0.0002588173,0.0001552552],"domain_scores_gemma":[0.9987819,0.00001258457,0.0005641218,0.0001985418,0.0003071066,0.0001357518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001518771,0.00009076051,0.001976792,0.00008963383,0.00008892212,0.00001920699,0.000110641,0.000004844168,0.9963549,0.000003122477,0.00006313868,0.001046208],"study_design_scores_gemma":[0.0006531164,0.0005300632,0.000705768,0.000111681,0.0000806592,0.00005527641,0.0001466931,0.000007898231,0.996847,0.00007130075,0.0006878732,0.0001026452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912855,0.003132348,0.001786271,0.00005625812,0.00009863197,0.00005246329,0.000003366662,0.000002145795,0.003583018],"genre_scores_gemma":[0.9963621,0.0004846434,0.002408082,0.00002125972,0.0004390265,0.000001746807,0.00001041504,0.00001625612,0.0002564179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005076656,"threshold_uncertainty_score":0.4319293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03369016429217422,"score_gpt":0.254868231379411,"score_spread":0.2211780670872368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}