{"id":"W2033078160","doi":"10.1021/jm200045v","title":"Small-Molecule Ligands of Methyl-Lysine Binding Proteins","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Chemistry; Lysine; Histone; Small molecule; Peptide; Histone H3; Biochemistry; Epigenetics; Chromatin; Binding site; Stereochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000173213,0.0003488954,0.0003130728,0.000127201,0.0001877315,0.0003199372,0.0004542518,0.0003846254,0.002030724],"category_scores_gemma":[0.0002470194,0.0001604297,0.0001874963,0.0001131314,0.0002106903,0.0001432794,0.0002229705,0.0006400766,0.0008223401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005370429,"about_ca_system_score_gemma":0.0002269819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005213075,"about_ca_topic_score_gemma":0.000898363,"domain_scores_codex":[0.9998661,0.00003730024,0.000006080845,0.00002379809,0.00003654974,0.00003011002],"domain_scores_gemma":[0.9999163,0.00002911382,0.00001482819,0.000007071791,0.00001073542,0.00002201763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002513655,0.00009361399,0.0001629812,0.0001454921,0.00002011941,0.000118062,0.00002848125,0.001538771,0.9880107,0.001607111,0.00056375,0.007459581],"study_design_scores_gemma":[0.0001527758,0.0006427128,0.0003873255,0.00001371484,0.00001863048,0.0002566144,0.00001779985,0.004780916,0.9796123,0.0002205563,0.01387968,0.00001692946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9348395,0.01037411,0.03889215,0.0007337988,0.0001833027,0.0003141648,0.0007578752,0.0005396393,0.01336539],"genre_scores_gemma":[0.9754318,0.002450283,0.01343165,0.0003277243,0.0000287122,0.0002078364,0.0006807435,0.0000332099,0.007407969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002030724,"threshold_uncertainty_score":0.006793499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03369016429217422,"score_gpt":0.254868231379411,"score_spread":0.2211780670872368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}