{"id":"W2033093171","doi":"10.1371/journal.pone.0051045","title":"Construction of Opa-Positive and Opa-Negative Strains of Neisseria meningitidis to Evaluate a Novel Meningococcal Vaccine","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Sanofi Pasteur; University of Oxford; Action Medical Research; National Institute for Health and Care Research; Sanofi; GlaxoSmithKline; Pfizer","keywords":"Neisseria meningitidis; Microbiology; Meningococcal disease; Meningococcal vaccine; Biology; Bacterial outer membrane; Virology; Bacterial adhesin; Neisseriaceae; Neisseria; Antibody; Gene; Bacteria; Genetics; Virulence; Escherichia coli; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002433177,0.0005533741,0.0003618734,0.0003118193,0.0001287333,0.0002765244,0.0004296373,0.0003350149,0.0008488444],"category_scores_gemma":[0.0002317887,0.0001711799,0.0003448392,0.0002689119,0.0002209727,0.0001959882,0.000304559,0.000736876,0.0002919793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003140491,"about_ca_system_score_gemma":0.0002358426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059324,"about_ca_topic_score_gemma":0.001050451,"domain_scores_codex":[0.9997265,0.00004472553,0.00003468272,0.0000425679,0.0001026838,0.00004885631],"domain_scores_gemma":[0.9998639,0.00002434507,0.00003813725,0.00002370029,0.00002028957,0.00002968331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009108482,0.0001248377,0.0002019137,0.00003290789,0.000006837404,0.00003412367,0.00001669726,0.0001830518,0.9982271,0.0001212389,0.00002516832,0.0009351851],"study_design_scores_gemma":[0.00003637754,0.0009778397,0.002314816,0.00001054001,0.00003964801,0.0002112505,0.00003611211,0.001265654,0.9917379,0.00007492707,0.003286824,0.000008102447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926066,0.0004754779,0.004757113,0.00006574871,0.00004736045,0.0002983665,0.0005994495,0.00003430441,0.001115618],"genre_scores_gemma":[0.9745479,0.0007535804,0.01841137,0.00008868798,0.00002104335,0.0003555431,0.002418649,0.00004834576,0.003354962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059324,"threshold_uncertainty_score":0.002839625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03820956808584119,"score_gpt":0.2624849007014687,"score_spread":0.2242753326156275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}