{"id":"W2033103604","doi":"10.4161/epi.6.2.13658","title":"Promoter context determines the role of proteasome in ligand-dependent occupancy of retinoic acid responsive elements","year":2011,"lang":"en","type":"article","venue":"Epigenetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Proteasome; Coactivator; Biology; Retinoic acid receptor; Retinoic acid; Retinoid X receptor; Activator (genetics); Transcription factor; Cell biology; Transcription (linguistics); Nuclear receptor; Ubiquitin; Context (archaeology); Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003676853,0.0001593913,0.0002057277,0.00005437898,0.00003086886,0.000005011861,0.000341359,0.0001384348,0.0000378351],"category_scores_gemma":[0.0001648839,0.0001226936,0.00008234526,0.00008851267,0.0001341231,0.000002840949,0.0001706209,0.00009779794,0.000005744449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000713532,"about_ca_system_score_gemma":0.00009036366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003827254,"about_ca_topic_score_gemma":0.0000992634,"domain_scores_codex":[0.9987102,0.00015824,0.0004676642,0.0002509559,0.000170999,0.0002419387],"domain_scores_gemma":[0.9990467,0.00001425842,0.0002603611,0.0004867167,0.0001445726,0.00004734173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003198347,0.0001241596,0.07560291,0.00003563209,0.00003199692,0.00000305381,0.001120493,5.696099e-7,0.9111868,0.00005720959,0.00001098816,0.01150632],"study_design_scores_gemma":[0.0004713721,0.0006789984,0.01957511,0.00004960584,0.00001496467,0.000005309107,0.0003320311,0.000009371868,0.9763435,0.0006912177,0.001695347,0.0001331428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951311,0.002621691,0.0000486645,0.00002074103,0.00006276257,0.0007564242,0.00005016006,0.000004241272,0.001304155],"genre_scores_gemma":[0.9984327,0.000182261,0.0009312212,0.00005287781,0.00005598937,0.00008823115,0.00001322566,0.00002131036,0.0002221762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0651567,"threshold_uncertainty_score":0.5003299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029823167497017,"score_gpt":0.2443962806593455,"score_spread":0.2240980489843754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}