{"id":"W2033127062","doi":"10.1074/jbc.m113.527747","title":"Structure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 Epitope","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Eusko Jaurlaritza; National Science Foundation","keywords":"Gp41; Epitope; Paratope; Immunogenicity; V3 loop; Chemistry; Peptide; Neutralization; Biophysics; Liposome; Adjuvant; Lipid bilayer; Virology; Antibody; Membrane; Biology; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080313,0.0002400393,0.0001049861,0.00010968,0.00007283343,0.0001304027,0.00009340726,0.0002604222,0.0004005975],"category_scores_gemma":[0.0001409759,0.00006687659,0.0001445785,0.00005684619,0.000103001,0.0001656779,0.0001049993,0.0002662704,0.0001132589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001283427,"about_ca_system_score_gemma":0.0001032047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001632418,"about_ca_topic_score_gemma":0.0001230531,"domain_scores_codex":[0.9999385,0.00001117785,0.00000331012,0.00001278242,0.0000188368,0.00001535343],"domain_scores_gemma":[0.9999648,0.000006864668,0.00001044166,0.000003638607,0.000005393527,0.000008777607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001206748,0.00004419696,0.0003595361,0.00002056045,0.000005684581,0.00003873874,0.000009873673,0.0004887119,0.9973761,0.00006742819,0.00001735339,0.00145118],"study_design_scores_gemma":[0.00003876746,0.00264694,0.0107649,0.00000988252,0.00003785551,0.000537912,0.00002368684,0.005048357,0.9789531,0.0001091466,0.001822484,0.00000697309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986705,0.0002842631,0.0007457323,0.00001528522,0.000004459823,0.000009162272,0.0000597437,0.00000423151,0.0002067293],"genre_scores_gemma":[0.9982577,0.0001719218,0.0008918287,0.0000201946,0.000003796856,0.000009017554,0.0003283446,0.000003061002,0.0003141958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004005975,"threshold_uncertainty_score":0.001340151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02654475888358978,"score_gpt":0.2639496370778081,"score_spread":0.2374048781942183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}