{"id":"W2033136380","doi":"10.1016/j.bmc.2004.03.075","title":"Synthesis and immunochemical characterization of protein conjugates of carbohydrate and carbohydrate-mimetic peptides as experimental vaccines","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Reductive amination; Conjugate; Bovine serum albumin; Glycoconjugate; Hapten; Biochemistry; Polysaccharide; Shigella flexneri; Peptide; Arabinogalactan; Linker; Stereochemistry; Escherichia coli; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002946511,0.0003171385,0.0002592781,0.0002819782,0.0001968234,0.0002797084,0.0002399999,0.0003049948,0.0008424585],"category_scores_gemma":[0.0004045582,0.0001833036,0.0002331285,0.000250208,0.0002318824,0.0002732953,0.000161135,0.0003944733,0.0002623724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002870878,"about_ca_system_score_gemma":0.0002023956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002171395,"about_ca_topic_score_gemma":0.0002020127,"domain_scores_codex":[0.9998553,0.00003462235,0.00001075454,0.00002341182,0.00003836722,0.000037536],"domain_scores_gemma":[0.9998609,0.00004761331,0.00002738903,0.00002058561,0.00002228486,0.00002121433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001413443,0.00004266785,0.0001090342,0.00002630807,0.000004145881,0.00003778781,0.00001276203,0.0002345835,0.9982215,0.0002409845,0.00001622811,0.0009126588],"study_design_scores_gemma":[0.00001053263,0.0001538934,0.0004535106,0.000001385298,0.000006286129,0.00006178314,0.000004844345,0.0003644675,0.9983383,0.0000466797,0.0005564882,0.000001764663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899525,0.000858797,0.007609968,0.00004983236,0.00002092321,0.00007434891,0.0002183815,0.00002545948,0.001189927],"genre_scores_gemma":[0.9909339,0.0006221135,0.005989852,0.00004464397,0.00001381673,0.00006030929,0.0006132002,0.00002458001,0.001697573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008424585,"threshold_uncertainty_score":0.002818286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006677715026503487,"score_gpt":0.2398743986025463,"score_spread":0.2331966835760428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}