{"id":"W2033172239","doi":"10.1038/leu.2011.99","title":"Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy","year":2011,"lang":"en","type":"article","venue":"Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Toronto General Hospital","funders":"National Institutes of Health; Government of Ontario; Ontario Institute for Cancer Research","keywords":"Ex vivo; Medicine; Granzyme; Immunotherapy; Perforin; CD8; Immunology; Myeloid leukemia; Leukemia; Granzyme B; Cancer research; CD34; Adoptive cell transfer; Peripheral blood mononuclear cell; Granzyme A; T cell; In vivo; Stem cell; Biology; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000360816,0.0005048102,0.001109244,0.0002675872,0.00008686374,0.00002497797,0.0004591153,0.000437038,0.005489744],"category_scores_gemma":[0.00003819527,0.0004171338,0.0004544584,0.0003517232,0.0003178688,0.0001318864,0.0001509131,0.0006833666,0.0001858274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001287907,"about_ca_system_score_gemma":0.0006006829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00552985,"about_ca_topic_score_gemma":0.00002495971,"domain_scores_codex":[0.9968245,0.000215442,0.0006806672,0.0007094644,0.0008357581,0.000734177],"domain_scores_gemma":[0.9978541,0.000253824,0.0003213465,0.00103222,0.0002734766,0.0002650318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005772837,0.0004721335,0.009579931,0.0001275501,0.0003774314,0.00007168972,0.002751344,0.00002227027,0.9684758,0.000003857196,0.0008026408,0.01154256],"study_design_scores_gemma":[0.01876593,0.003240081,0.05972113,0.0001588459,0.0001804784,0.00001525597,0.0001519491,0.0005946944,0.9158785,0.00002005257,0.0008891462,0.0003839555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891921,0.0002710753,0.0006180824,0.000007924288,0.0005735138,0.00140611,0.0001345473,0.000132551,0.007664053],"genre_scores_gemma":[0.9946949,0.0002298901,0.001678284,0.0001699849,0.0002136978,0.00005842372,0.0001002145,0.0001275334,0.002727021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05259728,"threshold_uncertainty_score":0.999828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01433966809170706,"score_gpt":0.2535317871441942,"score_spread":0.2391921190524872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}