{"id":"W2033172239","doi":"10.1038/leu.2011.99","title":"Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy","year":2011,"lang":"en","type":"article","venue":"Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Toronto General Hospital","funders":"National Institutes of Health; Government of Ontario; Ontario Institute for Cancer Research","keywords":"Ex vivo; Medicine; Granzyme; Immunotherapy; Perforin; CD8; Immunology; Myeloid leukemia; Leukemia; Granzyme B; Cancer research; CD34; Adoptive cell transfer; Peripheral blood mononuclear cell; Granzyme A; T cell; In vivo; Stem cell; Biology; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148747,0.0001882738,0.0003060618,0.0001522122,0.00009369291,0.0002576846,0.0001327406,0.0001491764,0.00182281],"category_scores_gemma":[0.0001331134,0.00007234327,0.0001237087,0.00008386702,0.0001279436,0.0001262513,0.0001362159,0.0003796545,0.0002120335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007838278,"about_ca_system_score_gemma":0.0001698622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001969898,"about_ca_topic_score_gemma":0.0002747626,"domain_scores_codex":[0.9999317,0.00002120649,0.000005491327,0.00001322573,0.00001210247,0.0000161918],"domain_scores_gemma":[0.9999628,0.00001561979,0.000003385893,0.000007471022,0.000003517841,0.000007161457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002353402,0.0006556539,0.002770944,0.000120377,0.00002765979,0.000471052,0.00007593756,0.000793151,0.9413183,0.0006041786,0.0003368152,0.05047261],"study_design_scores_gemma":[0.001158452,0.008504328,0.02295843,0.00002597682,0.0002166913,0.003689983,0.0001144751,0.003975993,0.9417238,0.0005718746,0.01704722,0.00001274859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939771,0.001335258,0.001614027,0.0001025448,0.00004892075,0.00004805073,0.0001286405,0.00003099035,0.002714477],"genre_scores_gemma":[0.9975457,0.0004407005,0.0007187898,0.00004161863,0.0000330279,0.00002069587,0.0002120423,0.000003839114,0.0009835192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00182281,"threshold_uncertainty_score":0.006097853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01433966809170706,"score_gpt":0.2535317871441942,"score_spread":0.2391921190524872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}