{"id":"W2033181361","doi":"10.1021/mp5007129","title":"Design and Function of Engineered Protein Nanocages as a Drug Delivery System for Targeting Pancreatic Cancer Cells via Neuropilin-1","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Ministry of Health, Labour and Welfare; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Nanocages; Nanocarriers; Chemistry; Pancreatic cancer; Cancer cell; Cancer research; Linker; Drug delivery; Peptide; Cell biology; Biochemistry; Biophysics; Cancer; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008896043,0.0002137688,0.0002791096,0.00008000421,0.00007181085,0.00004842607,0.000158253,0.00005614903,0.00001145701],"category_scores_gemma":[0.00006715211,0.0002116684,0.00005339113,0.0001659453,0.00006775251,0.0001377873,0.00007061866,0.00008622091,0.00002282802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001103404,"about_ca_system_score_gemma":0.0001892203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000857175,"about_ca_topic_score_gemma":8.017183e-7,"domain_scores_codex":[0.9982443,0.0003198128,0.0003789655,0.0003410338,0.0003319104,0.0003839873],"domain_scores_gemma":[0.9989623,0.0001180748,0.0001854843,0.0002092124,0.0003086751,0.0002162703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004025448,0.0000495583,0.00001201007,0.0004557677,0.00002908481,0.0000281829,0.0002077247,0.02621845,0.9717501,0.00002743181,0.0001132346,0.0007059496],"study_design_scores_gemma":[0.001252225,0.0001469119,0.000001414148,0.00009025658,0.0002166483,0.000004907262,0.0001217656,0.09348565,0.9041578,0.00004417048,0.0002842449,0.0001939802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8712662,0.002531054,0.1243371,0.00005213805,0.0004326907,0.001244313,0.00002186918,0.0001063197,0.000008351631],"genre_scores_gemma":[0.9894745,0.00002417763,0.01001002,0.0001242002,0.00005608071,0.0002155179,0.000004429246,0.00005014801,0.00004086769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1182083,"threshold_uncertainty_score":0.8631586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02504492917217307,"score_gpt":0.262972196081894,"score_spread":0.237927266909721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}