{"id":"W2033229916","doi":"10.1006/abio.2000.4638","title":"Quantitative Determination of a Chemically Modified Hammerhead Ribozyme in Blood Plasma Using 96-Well Solid-Phase Extraction Coupled with High-Performance Liquid Chromatography or Capillary Gel Electrophoresis","year":2000,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Optech (Canada)","funders":"Eli Lilly and Company","keywords":"Chromatography; Bioanalysis; Capillary electrophoresis; Hammerhead ribozyme; Chemistry; High-performance liquid chromatography; Solid phase extraction; Extraction (chemistry); Analyte; Ribozyme; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001600269,0.000938066,0.0007384482,0.0007119838,0.0004184565,0.0008768916,0.0006850584,0.001121583,0.001266435],"category_scores_gemma":[0.001748423,0.0004720013,0.0004291798,0.0005706009,0.0009132287,0.0005456741,0.0003171551,0.001006294,0.0008814067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005122848,"about_ca_system_score_gemma":0.0008366111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004744356,"about_ca_topic_score_gemma":0.001147834,"domain_scores_codex":[0.9983972,0.000541123,0.0001041801,0.000413976,0.0004158282,0.0001277285],"domain_scores_gemma":[0.9993184,0.0003511748,0.00006781887,0.00009320462,0.0001004028,0.00006902509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005740296,0.00008785941,0.00072926,0.00008572256,0.00003712567,0.00004775922,0.00006913923,0.0001454633,0.9905347,0.0002610341,0.0001598575,0.007268158],"study_design_scores_gemma":[0.00007219717,0.0007075273,0.004159999,0.00001685572,0.00007187483,0.000333695,0.00001969622,0.00351052,0.9891845,0.0003493079,0.001552096,0.00002181267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6570536,0.01446396,0.3172966,0.0007401417,0.0007238994,0.0008906281,0.002212025,0.00232405,0.004295049],"genre_scores_gemma":[0.7243702,0.004635504,0.2537514,0.0009414455,0.0004208867,0.001538348,0.002763125,0.0001811441,0.01139796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600269,"threshold_uncertainty_score":0.008463085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272859244182943,"score_gpt":0.2883372055987258,"score_spread":0.2756086131568963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}