{"id":"W2033236225","doi":"10.1371/journal.pone.0084673","title":"Identification of Adaptive Mutations in the Influenza A Virus Non-Structural 1 Gene That Increase Cytoplasmic Localization and Differentially Regulate Host Gene Expression","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; University of Ottawa","keywords":"Biology; Gene; Mutant; Influenza A virus; Gene expression; Molecular biology; Virus; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023522,0.0003677315,0.0002145509,0.0001869978,0.00009597778,0.0001706806,0.0001643241,0.0002145324,0.0006000827],"category_scores_gemma":[0.00009743552,0.0001168994,0.0002337903,0.0001246155,0.0002069923,0.00006387664,0.0001481872,0.0003703703,0.0001839846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004342038,"about_ca_system_score_gemma":0.0002084154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001283364,"about_ca_topic_score_gemma":0.002680615,"domain_scores_codex":[0.9998744,0.00001859663,0.00001076896,0.00003611434,0.00003230028,0.00002789675],"domain_scores_gemma":[0.9999056,0.00001990909,0.00003168673,0.00001204846,0.000009802321,0.00002097447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003793786,0.00001792215,0.0002489862,0.000007923578,0.000002696206,0.00002996342,0.000006757104,0.00002742278,0.9992552,0.00001576023,0.000009888964,0.0003394886],"study_design_scores_gemma":[0.00002901455,0.000778887,0.03440121,0.000007124615,0.00003185196,0.0007559014,0.00006285272,0.001771669,0.9604429,0.00002698417,0.001680859,0.00001094389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982035,0.0002077227,0.0008217252,0.00002166343,0.000009035314,0.00002422753,0.0003244064,0.00003370859,0.000353886],"genre_scores_gemma":[0.996166,0.0002516062,0.001729935,0.00004666308,0.000005529419,0.00003689446,0.0006107716,0.00003794768,0.00111462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001283364,"threshold_uncertainty_score":0.003150403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0694472885920224,"score_gpt":0.3026736700661963,"score_spread":0.2332263814741739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}