{"id":"W2033263306","doi":"10.1006/bbrc.2002.6349","title":"γ-Secretase-like Cleavages of Notch and βAPP Are Mutually Exclusive in Human Cells","year":2002,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Presenilin; HEK 293 cells; Notch signaling pathway; Cell biology; Intracellular; Amyloid precursor protein secretase; Cleavage (geology); Transmembrane protein; Alpha secretase; Notch 1; Amyloid precursor protein; Biology; Chemistry; Biochemistry; Signal transduction; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003332807,0.0001419171,0.0002719813,0.0002564677,0.0001944839,0.0009752412,0.0001495916,0.0001701207,0.001578893],"category_scores_gemma":[0.0005946386,0.0002104907,0.000258525,0.0002691769,0.0002113057,0.0003666299,0.0002474119,0.0003524972,0.0005537814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002709029,"about_ca_system_score_gemma":0.0003531764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008914499,"about_ca_topic_score_gemma":0.0007381837,"domain_scores_codex":[0.999653,0.00006890842,0.00005265916,0.0000738079,0.00008395527,0.00006756858],"domain_scores_gemma":[0.9995943,0.0001193529,0.00008157787,0.00008377703,0.0000749465,0.00004604261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001145174,0.00002770246,0.004581402,0.00005978375,0.00003623869,0.0004429125,0.0001147893,0.00004779531,0.9878829,0.0005100445,0.0001113819,0.005039766],"study_design_scores_gemma":[0.00006606393,0.0003058117,0.0498556,0.0000238515,0.00009114362,0.006011817,0.0004260198,0.0003917701,0.9353294,0.0005397483,0.006944039,0.00001461507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905018,0.005096305,0.001407785,0.00007084096,0.00001705274,0.00001274874,0.0004093741,0.00001734148,0.002466781],"genre_scores_gemma":[0.9950612,0.001534119,0.0007761199,0.00004701312,0.000007917502,0.00001334979,0.0007502942,0.000007340167,0.001802504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001578893,"threshold_uncertainty_score":0.005281925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.11691974948947,"score_gpt":0.3933437737325198,"score_spread":0.2764240242430499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}