{"id":"W2033289742","doi":"10.1016/j.mad.2012.11.002","title":"Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs","year":2012,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"National Institute of Environmental Health Sciences; National Institute on Aging; University of Pittsburgh; Cancer Institute, University of Pittsburgh; National Cancer Institute; National Institutes of Health; Ministerio de Economía y Competitividad; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Pittsburgh Foundation","keywords":"DNA damage; ERCC1; DNA repair; Senescence; Aggrecan; Apoptosis; Oxidative stress; Intervertebral disc; Degeneration (medical); Chemistry; Molecular biology; Biology; Medicine; Pathology; Cancer research; Internal medicine; DNA; Anatomy; Biochemistry; Nucleotide excision repair; Osteoarthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002583318,0.0001682208,0.0003692457,0.0001728983,0.00005017967,0.00001221304,0.00006351509,0.0001024142,0.0001228033],"category_scores_gemma":[0.00006073445,0.0001353498,0.00003506421,0.000115004,0.00003350715,0.00009778611,0.0001112996,0.0001241438,0.000008496229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007067085,"about_ca_system_score_gemma":0.00003979968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007510743,"about_ca_topic_score_gemma":0.0005492104,"domain_scores_codex":[0.9989838,0.00005158069,0.0002942883,0.0001864914,0.0001422373,0.0003415736],"domain_scores_gemma":[0.999655,0.00000668434,0.00009153117,0.00009479436,0.00004275053,0.0001092182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001414487,0.002493005,0.09308522,0.000713456,0.0006038564,0.0006912935,0.0335348,0.00000772056,0.8090985,0.00567613,0.0009783778,0.05297621],"study_design_scores_gemma":[0.0008531751,0.0002891517,0.4587611,0.0003297881,0.00001872145,0.00001390356,0.001128881,0.0000413916,0.538201,0.0001692146,0.00004155166,0.0001520573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959747,0.0004106431,0.00266764,0.0002167088,0.0001627271,0.0002095165,0.000006654534,0.00002975064,0.0003217143],"genre_scores_gemma":[0.9903814,0.00003452878,0.008574824,0.0003914424,0.00002898937,0.00004084506,0.00006621474,0.00001615643,0.0004655909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3656759,"threshold_uncertainty_score":0.5519406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03852471386540394,"score_gpt":0.2825137865879472,"score_spread":0.2439890727225432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}