{"id":"W2033322873","doi":"10.1007/s12265-014-9603-3","title":"Statins Impair Survival of Primary Human Mesenchymal Progenitor Cells via Mevalonate Depletion, NF-κB Signaling, and Bnip3","year":2014,"lang":"en","type":"article","venue":"Journal of Cardiovascular Translational Research","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta Hospital; University of Alberta; University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Simvastatin; Pravastatin; Atorvastatin; Viability assay; HMG-CoA reductase; Mesenchymal stem cell; Progenitor cell; Pharmacology; Mevalonate pathway; Biology; Statin; Cancer research; NFKB1; Cell biology; Chemistry; Reductase; Stem cell; Endocrinology; Cell; Cholesterol; Biochemistry; Transcription factor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002285078,0.0003307267,0.0005144989,0.0002682766,0.0003654496,0.0006223447,0.0002350168,0.0003359423,0.002394413],"category_scores_gemma":[0.0001938923,0.0001985907,0.0005885101,0.0003048501,0.0002378259,0.00026824,0.0003475634,0.0009968213,0.000617476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003029619,"about_ca_system_score_gemma":0.0008530026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002977381,"about_ca_topic_score_gemma":0.00489501,"domain_scores_codex":[0.999642,0.00004123821,0.00005803863,0.00004200355,0.00009698567,0.0001197106],"domain_scores_gemma":[0.9998938,0.00001589053,0.00002582586,0.00001617248,0.00001836697,0.00002997184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00315624,0.0002534534,0.001518277,0.0001501488,0.00007019987,0.0001607424,0.00007336815,0.000158577,0.9884109,0.0002183072,0.0004719324,0.00535778],"study_design_scores_gemma":[0.0001863061,0.001685748,0.01854733,0.00003285762,0.0001390547,0.000379536,0.0002904148,0.001001767,0.9719297,0.0001676909,0.005624332,0.00001522195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917578,0.003058433,0.001427612,0.0003723362,0.0001170029,0.00004307923,0.001380813,0.0000613158,0.00178144],"genre_scores_gemma":[0.9926438,0.002047983,0.0008328553,0.0001629135,0.00001683802,0.00008258519,0.001622247,0.00001127037,0.002579496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002977381,"threshold_uncertainty_score":0.008010089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07348976607983626,"score_gpt":0.3757633184950985,"score_spread":0.3022735524152622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}