{"id":"W2033407284","doi":"10.1021/ol060802k","title":"Asymmetric Synthesis of Hexapropionate Synthons by Sequential Enantiotopic Group Selective Enolization of Meso Diketones","year":2006,"lang":"en","type":"article","venue":"Organic Letters","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Stereocenter; Synthon; Aldol reaction; Kinetic resolution; Keto–enol tautomerism; Enantioselective synthesis; Enol; Aldehyde; Amide; Stereochemistry; Amine gas treating; Organic chemistry; Tautomer; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514003,0.000597119,0.0002505713,0.0002075068,0.0001269578,0.0003070626,0.0002851909,0.0001605587,0.002905928],"category_scores_gemma":[0.0001275057,0.000175347,0.0001527092,0.0001539544,0.0001662544,0.0002556498,0.0003729673,0.0004448468,0.001471648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002162812,"about_ca_system_score_gemma":0.0002422051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002328781,"about_ca_topic_score_gemma":0.000575464,"domain_scores_codex":[0.9999008,0.00001341779,0.00001037886,0.00001950884,0.00002253684,0.00003334737],"domain_scores_gemma":[0.9999236,0.00001023159,0.00001822754,0.00001004779,0.0000103367,0.00002749451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002196785,0.00003201699,0.0001441169,0.00009986755,0.000009808198,0.0007763653,0.00005563488,0.0006407458,0.9870172,0.00136449,0.0003676673,0.009272438],"study_design_scores_gemma":[0.00005065825,0.0001569479,0.0005080889,0.00000641167,0.00001065872,0.0003136412,0.00003179322,0.0007386969,0.9913015,0.0001878268,0.006682643,0.0000110862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385789,0.00179944,0.0235199,0.0003529246,0.0003006421,0.0002438712,0.001350329,0.0004788422,0.03337519],"genre_scores_gemma":[0.981208,0.001425573,0.007648865,0.00006290087,0.00002645674,0.00005286514,0.0004421197,0.00005420806,0.009079013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002905928,"threshold_uncertainty_score":0.009721339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004465082359156562,"score_gpt":0.1932067339161739,"score_spread":0.1887416515570173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}